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Citation
Jiang, H., Edgar, B.A. (2009). EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors.  Development 136(3): 483--493.
FlyBase ID
FBrf0206542
Publication Type
Research paper
Abstract

In holometabolous insects, the adult appendages and internal organs form anew from larval progenitor cells during metamorphosis. As described here, the adult Drosophila midgut, including intestinal stem cells (ISCs), develops from adult midgut progenitor cells (AMPs) that proliferate during larval development in two phases. Dividing AMPs first disperse, but later proliferate within distinct islands, forming large cell clusters that eventually fuse during metamorphosis to make the adult midgut epithelium. We find that signaling through the EGFR/RAS/MAPK pathway is necessary and limiting for AMP proliferation. Midgut visceral muscle produces a weak EGFR ligand, Vein, which is required for early AMP proliferation. Two stronger EGFR ligands, Spitz and Keren, are expressed by the AMPs themselves and provide an additional, autocrine mitogenic stimulus to the AMPs during late larval stages.

PubMed ID
PubMed Central ID
PMC2687592 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (1)
    Alleles (44)
    Genes (25)
    Natural transposons (1)
    Insertions (9)
    Experimental Tools (1)
    Transgenic Constructs (22)
    Transcripts (5)