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Sung, C., Wong, L.E., Chang Sen, L.Q., Nguyen, E., Lazaga, N., Ganzer, G., McNabb, S.L., Robinow, S. (2009). The unfulfilled/DHR51 gene of Drosophila melanogaster modulates wing expansion and fertility.  Dev. Dyn. 238(1): 171--182.
FlyBase ID
FBrf0206588
Publication Type
Research paper
Abstract

This is the first functional analysis in Drosophila of unfulfilled (unf; DHR51), the NR2E3 nuclear receptor superfamily ortholog of C. elegans fax-1 and human PNR. Both fax-1 and PNR mutations disrupt developmental events in a limited number of neurons, resulting in behavioral or sensory deficits. An analysis of two independent unf alleles revealed that unf mutants are characterized by one of two phenotypes. A proportion of the mutants eclosed but failed to expand their wings and were poorly coordinated. The remainder completed wing expansion but displayed severely compromised fertility. Consistent with the restricted neural expression of fax-1 and PNR, unf expression was detected in situ only in mushroom body neurons and a small number of other cells of the central nervous system (CNS). These data support the hypothesis that the wing expansion failure and the compromised fertility of unf mutants are the result of underlying neural defects.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Dyn.
    Title
    Developmental Dynamics
    Publication Year
    1992-
    ISBN/ISSN
    1058-8388
    Data From Reference
    Aberrations (1)
    Alleles (7)
    Genes (5)
    Natural transposons (1)
    Insertions (3)
    Transgenic Constructs (2)