Reference Report

Reference
Citation	Tang, S., Presgraves, D.C. (2009). Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities. Science 323(5915): 779--782. (Export to RIS)
FlyBase ID	FBrf0206719
Publication Type	Research paper
PubMed ID	19197064
PubMed Abstract	Speciation often involves the evolution of incompatible gene interactions that cause sterility or lethality in hybrids between populations. These so-called hybrid incompatibilities occur between two or more functionally divergent loci. We show that the nucleoporin 160kDa (Nup160) gene of the fruitfly Drosophila simulans is incompatible with one or more factors on the D. melanogaster X chromosome, causing hybrid lethality. Nup160 encodes a nuclear pore complex protein and shows evidence of adaptive evolution. Furthermore, the protein encoded by Nup160 directly interacts with that of another hybrid lethality gene, Nup96, indicating that at least two lethal hybrid incompatibility genes have evolved as byproducts of divergent coevolution among interacting components of the Drosophila nuclear pore complex.
DOI	10.1126/science.1169123
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Aberrations (6)
	C(1)A Df(2L)BSC36 Df(2L)Exel6027 Df(2L)Exel6028 Df(2L)Exel6029 Df(2L)FCK-20
Alleles (3)
	Nup160^e00704 Nup160^Scer\UAS.cTa Scer\GAL4^tub.PU
Constructs (2)
	P{tub-GAL4.U} P{UAS-Nup160.T}
Genes (5)
	Dsim\Nup160 Nup98-96 Nup160 RfC38 Scer\GAL4
Insertions (1)
	PBac{RB}RfC38^e00704
Natural transposons (1)
	P-element