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Reference Report
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| Citation | Hurlbut, G.D., Kankel, M.W., Artavanis-Tsakonas, S. (2009). Nodal points and complexity of Notch-Ras signal integration. Proc. Natl. Acad. Sci. U.S.A. 106(7): 2218--2223. (Export to RIS) | ||
| FlyBase ID | FBrf0206757 | ||
| Publication Type | Research paper | ||
| PubMed ID | 19171888 | ||
| PubMed Abstract | Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the larger-scale network they form through integration, as exemplified by cross-talk between the Notch and receptor tyrosine kinase (RTK) pathways. We examined the transcriptional output of Notch-RTK cross-talk during Drosophila development and present in vivo data supporting a role for selected mutually regulated genes in signal integration. Interestingly, Notch-RTK integration did not lead to general antagonism of either pathway, as is commonly believed. Instead, integration had a combinatorial effect on specific cross-regulated targets, which unexpectedly included numerous core components of the RTK and other major signaling pathways (TGF-beta, Hh, Jak/Stat, nuclear receptor and Wnt). We find the majority of Ras-responsive genes are also Notch-responsive, suggesting Notch may function to specify the response to Ras activation. | ||
| DOI | 10.1073/pnas.0812024106 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Proc. Natl. Acad. Sci. U.S.A. | ||
| Title | Proceedings of the National Academy of Sciences of the United States of America | ||
| Publication Year | 1915- | ||
| ISBN/ISSN | 0027-8424 | ||
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Data from Reference
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| Genes (48)
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