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Citation
Ricardo, S., Lehmann, R. (2009). An ABC transporter controls export of a Drosophila germ cell attractant.  Science 323(5916): 943--946.
FlyBase ID
FBrf0206762
Publication Type
Research paper
Abstract

Directed cell migration, which is critical for embryonic development, leukocyte trafficking, and cell metastasis, depends on chemoattraction. 3-hydroxy-3-methylglutaryl coenzyme A reductase regulates the production of an attractant for Drosophila germ cells that may itself be geranylated. Chemoattractants are commonly secreted through a classical, signal peptide-dependent pathway, but a geranyl-modified attractant would require an alternative pathway. In budding yeast, pheromones produced by a-cells are farnesylated and secreted in a signal peptide-independent manner, requiring the adenosine triphosphate-binding cassette (ABC) transporter Ste6p. Here we show that Drosophila germ cell migration uses a similar pathway, demonstrating that invertebrate germ cells, like yeast cells, are attracted to lipid-modified peptides. Components of this unconventional export pathway are highly conserved, suggesting that this pathway may control the production of similarly modified chemoattractants in organisms ranging from yeast to humans.

PubMed ID
PubMed Central ID
PMC2729540 (PMC) (EuropePMC)
Related Publication(s)
Note

Cell biology. The ABCs of lipophile transport.
Hla and Im, 2009, Science 323(5916): 883--884 [FBrf0215399]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Aberrations (3)
    Alleles (6)
    Genes (14)
    Cell Lines (1)
    Transgenic Constructs (2)