Reference Report

Reference
Citation	Zheng, Y., Wildonger, J., Ye, B., Zhang, Y., Kita, A., Younger, S.H., Zimmerman, S., Jan, L.Y., Jan, Y.N. (2008). Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat. Cell Biol. 10(10): 1172--1180. (Export to RIS)
FlyBase ID	FBrf0206898
Publication Type	Research paper
PubMed ID	18758451
PubMed Abstract	Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the orientation of axonal microtubules in Drosophila melanogaster dendritic arborization (da) neurons. Changes in organelle distribution within the dendritic arbors of dynein mutant neurons correlate with a proximal shift in dendritic branch position. Dynein is also necessary for the dendrite-specific localization of Golgi outposts and the ion channel Pickpocket. Axonal microtubules are normally oriented uniformly plus-end-distal; however, without dynein, axons contain both plus- and minus-end distal microtubules. These data suggest that dynein is required for the distinguishing properties of the axon and dendrites: without dynein, dendritic organelles and proteins enter the axon and the axonal microtubules are no longer uniform in polarity.
DOI	10.1038/ncb1777
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Cell Biol.
Title	Nature Cell Biology
Publication Year	1999-
ISBN/ISSN	1465-7392 1476-4679
Data from Reference
Alleles (19)
	Avic\GFP^{E.Scer\UAS.T:Uuuu\ManII} Dhc64C^4-19 Dlic¹¹⁵⁷ Dlic^{Scer\UAS.T:Avic\GFP-EGFP} Dmn^Scer\UAS.cDa Eb1^{Scer\UAS.T:Avic\GFP-EGFP} Khc::nod^{Scer\UAS.T:Ecol\lacZ} Khc^{Scer\UAS.T:Ecol\lacZ} Lis-1^G10.14 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rab4^{Scer\UAS.T:Disc\RFP} Scer\GAL4^2-21 Scer\GAL4^109(2)80 Scer\GAL4⁴⁷⁷ Scer\GAL4^ppk.PG spin^{Scer\UAS.T:Hcri\RFP} sw¹ sw¹²²⁹ T:Avic\GFP^EGFP
Constructs (10)
	P{ppk-GAL4.G} P{UAS-Dlic.EGFP} P{UAS-Dmn.D} P{UAS-Eb1.GFP} P{UAS-Khc::lacZ} P{UAS-Khc::nod::lacZ} P{UAS-ManII-EGFP} P{UAS-mCD8::GFP.L} P{UAS-Rab4-mRFP} P{UAS-spin-RFP.S}
Genes (15)
	Avic\GFP Dhc64C Dlic Dmn Eb1 Khc Khc::nod Lis-1 Mmus\Cd8a nod ppk Rab4 Scer\GAL4 spin sw
Insertions (3)
	P{GawB}2-21 P{GawB}109(2)80 P{GawB}477
Natural transposons (1)
	P-element