Reference Report

Reference
Citation	Kaspar, M., Schneider, M., Chia, W., Klein, T. (2008). Klumpfuss is involved in the determination of sensory organ precursors in Drosophila. Dev. Biol. 324(2): 177--191. (Export to RIS)
FlyBase ID	FBrf0207063
Publication Type	Research paper
PubMed ID	18831969
PubMed Abstract	The neural precursor cells (sensory organ precursor cell (SOP)) of the external sense organs of Drosophila melanogaster arise from proneural clusters, which are defined through the expression pattern of proneural genes such as the genes of the achaete-scute complex (AS-C). The activities of these genes enable each cell within a cluster to become the SOP. A selection process mediated by the Notch signalling pathway and Extramacrochaetae selects a defined number of cells within the proneural cluster to realise the SOP fate, while it redirects the rest to the epidermoblast fate. Here we report a new function required for SOP determination mediated by the zinc finger transcription factor Klumpfuss (Klu). Klu participates in a novel mechanism that appears to regulate the expression as well as the activity of the proneural proteins. Our analysis indicates that Klu is a repressor of transcription, which acts via a double-negative loop to promote SOP formation: it suppresses the expression of an unidentified antagonist of proneural activity. We present a detailed structure function analysis that identifies functionally important domains within Klu.
DOI	10.1016/j.ydbio.2008.08.031
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (2)
	Df(1)sc10-1 Df(3R)Espl22
Alleles (41)
	Avic\GFP^{Sm.E(spl).H-Stinger} da^11B6 Disc\RFP^{mα.H-Stinger} Ecol\lacZ^{Ddc.be2.E(spl).m8} Ecol\lacZ^{E(spl).-1166+87} Ecol\lacZ^emc-P5c Ecol\lacZ^miniEx4.E1 Ecol\lacZ^neur-A101 Ecol\lacZ^sc.PC Ecol\lacZ^sca-A2-6 gro^E48 klu^212lR51C klu^{350-583.Scer\UAS.T:Ivir\HA1,T:Uuuu\nls6} klu^G410 klu^{Scer\UAS.T:Hsap\MYC} klu^{Scer\UAS.T:Ivir\HA1,T:Hsim\VP16} klu^{Scer\UAS.T:Ivir\HA1,T:Rep-en} klu^{Scer\UAS.T:Ivir\HA1} klu^{Δ1-170.Scer\UAS.T:Ivir\HA1} klu^{Δ1-400.Scer\UAS.T:Ivir\HA1} klu^{Δ1-583.Scer\UAS.T:Ivir\HA1} klu^{Δ401-803.Scer\UAS.T:Ivir\HA1} klu^{Δ501-803.Scer\UAS.T:Ivir\HA1} klu^{Δ583-803.Scer\UAS.T:Ivir\HA1} klu^{Δ584-619.Scer\UAS.T:Ivir\HA1} klu^{Δ584-653.Scer\UAS.T:Ivir\HA1} klu^{Δ612-803.Scer\UAS.T:Ivir\HA1} klu^{Δ652-711.Scer\UAS.T:Ivir\HA1} klu^{Δ680-711.Scer\UAS.T:Ivir\HA1} klu^{Δ710-803.Scer\UAS.T:Ivir\HA1} l(1)sc^Scer\UAS.cPa Psn^C1 sc^Scer\UAS.cPa Scer\GAL4^Act5C.PI Scer\GAL4^dpp.blk1 Scer\GAL4^klu-G410 Scer\GAL4^pnr-MD237 Scer\GAL4^sca-537.4 Scer\GAL4^{Scer\FRT.Act5C} Scer\GAL4^tub.PU Su(H)^del47
Constructs (28)
	P{AyGAL4} P{Ddc.E(spl)-lacZ.Gbe.m8} P{E(spl).Green.H-Stinger.Sm} P{GAL4-dpp.blk1} P{m8-lacZ} P{mα.Red.H-Stinger} P{sc-lacZ.3.7} P{sc-lacZ.miniEx4.E1} P{tub-GAL4.U} P{UAS-HA-en-klu} P{UAS-HA-klu.350-583} P{UAS-HA-klu.Δ1-170} P{UAS-HA-klu.Δ1-400} P{UAS-HA-klu.Δ1-583} P{UAS-HA-klu.Δ401-803} P{UAS-HA-klu.Δ501-803} P{UAS-HA-klu.Δ583-803} P{UAS-HA-klu.Δ584-619} P{UAS-HA-klu.Δ584-653} P{UAS-HA-klu.Δ612-803} P{UAS-HA-klu.Δ652-711} P{UAS-HA-klu.Δ680-711} P{UAS-HA-klu.Δ710-803} P{UAS-HA-klu} P{UAS-HA-VP16-klu} P{UAS-klu.Myc} P{UAS-l'sc} P{UAS-sc.P}
Genes (21)
	ac Avic\GFP da Disc\RFP E(spl)m8-HLH E(spl)mα-BFM Ecol\lacZ gro klu l(1)sc peb Psn sc sca Scer\GAL4 Su(H) T:Hsim\VP16 T:Ivir\HA1 T:Rep-en T:Uuuu\nls6 wg
Insertions (6)
	P{A92}emc^P5c P{GAL4}klu^G410 P{GawB}pnr^MD237 P{GawB}sca^537.4 P{lacW}sca^A2-6 P{lArB}neur^A101
Natural transposons (1)
	P-element