Reference Report

Reference
Citation	Liu, X., Davis, R.L. (2009). The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning. Nat. Neurosci. 12(1): 53--59. (Export to RIS)
FlyBase ID	FBrf0207183
Publication Type	Research paper
PubMed ID	19043409
PubMed Abstract	GABAergic neurotransmitter systems are important for many cognitive processes, including learning and memory. We identified a single neuron in each hemisphere of the Drosophila brain, the anterior paired lateral (APL) neuron, as a GABAergic neuron that broadly innervated the mushroom bodies. Reducing GABA synthesis in the APL neuron enhanced olfactory learning, suggesting that the APL neuron suppressed learning by releasing the inhibitory neurotransmitter GABA. Functional optical-imaging experiments revealed that the APL neuron responded to both odor and electric-shock stimuli that was presented to the fly with increases of intracellular calcium and released neurotransmitter. Notably, a memory trace formed in the APL neuron by pairing odor with electric shock. This trace was detected as a reduced calcium response in the APL neuron after conditioning specifically to the trained odor. These results demonstrate a mutual suppression between the GABAergic APL neuron and olfactory learning, and emphasize the functional neuroplasticity of the GABAergic system as a result of learning.
DOI	10.1038/nn.2235
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Nat. Neurosci.
Title	Nature Neuroscience
Publication Year	1998-
ISBN/ISSN	1097-6256
Data from Reference
Alleles (7)
	Avic\GFP^{GCaMP1.6.Scer\UAS} Avic\GFP^{pHluorinE.Scer\UAS.T:Mmus\Vamp2} Gad1^GD8508 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\FLP1^hs.P Scer\GAL4^GH146 Scer\GAL80^Cha.PK
Constructs (6)
	P{Cha-GAL80.K} P{GD8508} P{hsp-FLP} P{UAS-G-CaMP.1.6} P{UAS-mCD8::GFP.L} P{UAS-synapto-pHluorinE.Vamp2}
Genes (6)
	Gad1 Mmus\Cd8a Scer\FLP1 Scer\GAL4 Scer\GAL80 T:Mmus\Vamp2
Insertions (1)
	P{GawB}GH146