Reference Report

Reference
Citation	Mouchel-Vielh, E., Bloyer, S., Salvaing, J., Randsholt, N.B., Peronnet, F. (2008). Involvement of the MP1 scaffold protein in ERK signaling regulation during Drosophila wing development. Genes Cells 13(11): 1099--1111. (Export to RIS)
FlyBase ID	FBrf0207254
Publication Type	Research paper
PubMed ID	18823331
PubMed Abstract	Mitogen-activated protein kinase (MAPK) cascades are evolutionary conserved transduction pathways involved in many cellular processes. Kinase modules are associated with scaffold proteins that regulate signaling by providing critical spatial and temporal specificities. Some of these scaffold proteins have been shown to be conserved, both in sequence and function. In mouse, the scaffold MP1 (MEK Partner 1) forms a signaling complex with MEK1 and ERK1. In this work, we focus on Drosophila MP1 (dMP1). We show that dMP1 is expressed ubiquitously during embryonic and larval development. By in vitro and in vivo experiments, we show that dMP1 is located in the cytoplasm and the nuclei, and that it interacts with MEK and ERK. Genetic studies with transgenic Drosophila lines allowing either dMP1 over-expression or dMP1 down-regulation by RNA interference highlight dMP1 function in the control of cell differentiation during development of the Drosophila wing.
DOI	10.1111/j.1365-2443.2008.01231.x
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Cells
Title	Genes to cells : devoted to molecular & cellular mechanisms
Publication Year	1996-
ISBN/ISSN	1356-9597
Data from Reference
Aberrations (1)
	Df(2L)ED1175
Alleles (11)
	CG5110^{dsRNA.Scer\UAS.P\T} CG5110^GD11538 CG5110^{Scer\UAS.P\T.cMVa} CG5110^{Scer\UAS.P\T.T:Disc\RFP-mRFP} rl^Scer\UAS.cKa Scer\GAL4^ap-md544 Scer\GAL4^da.G32 Scer\GAL4^en-e16E Scer\GAL4^hs.PB Scer\GAL4^sd-SG29.1 T:Disc\RFP^mRFP
Constructs (7)
	P{GAL4-da.G32} P{GAL4-Hsp70.PB} P{GD11538} P{UASp-CG5110.ds} P{UASp-CG5110.mRFP} P{UASp-CG5110.MV} P{UAS-rl.K}
Genes (4)
	CG5110 Dsor1 rl Scer\GAL4
Insertions (3)
	P{en2.4-GAL4}e16E P{GawB}ap^md544 P{GawB}sd^SG29.1
Natural transposons (1)
	P-element