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Citation
Kapelnikov, A., Zelinger, E., Gottlieb, Y., Rhrissorrakrai, K., Gunsalus, K.C., Heifetz, Y. (2008). Mating induces an immune response and developmental switch in the Drosophila oviduct.  Proc. Natl. Acad. Sci. U.S.A. 105(37): 13912--13917.
FlyBase ID
FBrf0207258
Publication Type
Research paper
Abstract

Mating triggers physiological and behavioral changes in females. To understand how females effect these changes, we used microarray, proteomic, and comparative analyses to characterize gene expression in oviducts of mated and unmated Drosophila females. The transition from non-egg laying to egg laying elicits a distinct molecular profile in the oviduct. Immune-related transcripts and proteins involved in muscle and polarized epithelial function increase, whereas cell growth and differentiation-related genes are down-regulated. Our combined results indicate that mating triggers molecular and biochemical changes that mediate progression from a "poised" state to a mature, functional stage.

PubMed ID
PubMed Central ID
PMC2544553 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference