Reference Report

Reference
Citation	Lin, Y.R., Reddy, B.V., Irvine, K.D. (2008). Requirement for a core 1 galactosyltransferase in the Drosophila nervous system. Dev. Dyn. 237(12): 3703--3714. (Export to RIS)
FlyBase ID	FBrf0207265
Publication Type	Research paper
PubMed ID	18985719
PubMed Abstract	Mucin type O-glycosylation is a widespread modification of eukaryotic proteins, but its functional requirements remain incompletely understood. It is initiated by the attachment of N-acetylgalactosamine (GalNAc) to Ser or Thr residues, and then elongated by additional sugars. We have examined requirements for mucin-type glycosylation in Drosophila by characterizing the expression and phenotypes of core 1 galactosyltransferases (core 1 GalTs), which elongate O-GalNAc by adding galactose in a beta1,3 linkage. Drosophila encode several putative core 1 GalTs, each expressed in distinct patterns. CG9520 (C1GalTA) is expressed in the amnioserosa and central nervous system. A null mutation in C1GalTA is lethal, and mutant animals exhibit a striking morphogenetic defect in which the ventral nerve cord is greatly elongated and the brain hemispheres are misshapen. Lectin staining and blotting experiments confirmed that C1GalTA contributes to the synthesis of Gal-beta1,3-GalNAc in vivo. Our results identify a role for mucin-type O-glycosylation during neural development in Drosophila.
DOI	10.1002/dvdy.21775
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Dyn.
Title	Developmental Dynamics
Publication Year	1992-
ISBN/ISSN	1058-8388
Data from Reference
Aberrations (3)
	Df(2L)ED647 Df(2L)Exel7040 Df(2L)N22-14
Alleles (9)
	C1GalTA^2.1 C1GalTA^30.1 C1GalTA^+tLa C1GalTA^KG02976 CG8708^KG05736 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^elav-C155 w^+mC wor¹
Constructs (3)
	P{?SUPor-P} P{C1GalTA^+tLa} P{UAS-mCD8::GFP.L}
Genes (20)
	C1GalTA CG2975 CG2983 CG3119 CG8708 CG18558 CG34056 CG34057 CrebA crq elav Fas2 LanB1 LanB2 Mmus\Cd8a repo Scer\GAL4 tgy w wor
Insertions (4)
	P{?SUPor-P}C1GalTA^2.1 P{GawB}elav^C155 P{SUPor-P}C1GalTA^KG02976 P{SUPor-P}CG8708^KG05736
Natural transposons (1)
	P-element