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Citation
Deng, X., Meller, V.H. (2009). Molecularly severe roX1 mutations contribute to dosage compensation in Drosophila.  genesis 47(1): 49--54.
FlyBase ID
FBrf0207276
Publication Type
Research paper
Abstract

Drosophila melanogaster males maintain a constant ratio of X-linked to autosomal gene products by increasing expression from their single X chromosome. This is achieved through the action of a complex composed of protein and roX RNA. This complex binds in the body of genes and increases expression through chromatin modification. The X-linked roX genes produce RNAs that are essential but redundant for recognition and modification of the male X chromosome. We report that some molecularly severe roX1 mutations with no detectable transcript accumulation contribute dramatically to male rescue by autosomal roX1 transgenes. We propose that this represents genetic complementation between a source of roX RNA (the autosomal transgene) and the severely mutated X-linked allele.

PubMed ID
PubMed Central ID
PMC5029428 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    genesis
    Title
    genesis
    Publication Year
    2000-
    ISBN/ISSN
    1526-954X 1526-968X
    Data From Reference
    Aberrations (1)
    Alleles (9)
    Genes (3)
    Natural transposons (1)
    Transgenic Constructs (6)