Reference Report

Reference
Citation	Kim, Y., Park, J., Kim, S., Song, S., Kwon, S.K., Lee, S.H., Kitada, T., Kim, J.M., Chung, J. (2008). PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 377(3): 975--980. (Export to RIS)
FlyBase ID	FBrf0207333
Publication Type	Research paper
PubMed ID	18957282
PubMed Abstract	PTEN-induced putative kinase 1 (PINK1) and Parkin, encoded by their respective genes associated with Parkinson's disease (PD), are linked in a common pathway involved in the protection of mitochondrial integrity and function. However, the mechanism of their interaction at the biochemical level has not been investigated yet. Using both mammalian and Drosophila systems, we here demonstrate that the PINK1 kinase activity is required for its function in mitochondria. PINK1 regulates the localization of Parkin to the mitochondria in its kinase activity-dependent manner. In detail, Parkin phosphorylation by PINK1 on its linker region promotes its mitochondrial translocation, and the RING1 domain of Parkin is critical for this occurrence. These results demonstrate the biochemical relationship between PINK1, Parkin, and the mitochondria and thereby suggest the possible mechanism of PINK-Parkin-associated PD pathogenesis.
DOI	10.1016/j.bbrc.2008.10.104
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Biochem. Biophys. Res. Commun.
Title	Biochemical and Biophysical Research Communications
Publication Year	1959-
ISBN/ISSN	0006-291X
Data from Reference
Alleles (9)
	park¹ park^{Scer\UAS.T:Hsap\MYC} park^{Scer\UAS.T:Zzzz\FLAG,T:Hsap\COX4I1} park^{Scer\UAS.T:Zzzz\FLAG,T:Mito-Tom20} park^{T187A.Scer\UAS.T:Hsap\MYC} Pink1^B9 Pink1^{K337R.D479A.D501A.Scer\UAS.T:Ivir\HA1} Pink1^{Scer\UAS.T:Ivir\HA1} Scer\GAL4^hs.PB
Constructs (7)
	P{GAL4-Hsp70.PB} P{UAS-park.FLAG.COX-IV} P{UAS-park.Flag.Tom20} P{UAS-park.MYC.T187A} P{UAS-park-Myc} P{UAS-Pink1.HA.KD} P{UAS-Pink1.HA}
Genes (9)
	park Pink1 Scer\GAL4 T:Hsap\COX4I1 T:Hsap\MYC T:Ivir\HA1 T:Mito-Tom20 T:Zzzz\FLAG Tom20
Natural transposons (1)
	P-element