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Citation
Eid, J.P., Martinez Arias, A., Robertson, H., Hime, G.R., Dziadek, M. (2008). The Drosophila STIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning.  BMC Dev. Biol. 8(): 104.
FlyBase ID
FBrf0207338
Publication Type
Research paper
Abstract
Mammalian STIM1 and STIM2 and the single Drosophila homologue dSTIM have been identified as key regulators of store-operated Ca2+ entry in cells. STIM proteins function both as molecular sensors of Ca2+concentration in the endoplasmic reticulum (ER) and the molecular triggers that activate SOC channels in the plasma membrane. Ca2+ is a crucial intracellular messenger utilised in many cellular processes, and regulators of Ca2+ homeostasis in the ER and cytosol are likely to play important roles in developmental processes. STIM protein expression is altered in several tumour types but the role of these proteins in developmental signalling pathways has not been thoroughly examined.We have investigated the expression and developmental function of dSTIM in Drosophila and shown that dSTIM is widely expressed in embryonic and larval tissues. Using the UAS-Gal4 induction system, we have expressed full-length dSTIM protein and a dsRNAi construct in different tissues. We demonstrate an essential role for dSTIM in larval development and survival, and a tissue-specific role in specification of mechanosensory bristles in the notum and specification of wing vein thickness.Our studies show that dSTIM regulates growth and patterning of imaginal discs and indicate potential interactions with the Notch and Wingless signaling pathways. These interactions may be relevant to studies implicating STIM family proteins in tumorigenesis.
PubMed ID
PubMed Central ID
PMC2584103 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BMC Dev. Biol.
    Title
    BMC Developmental Biology
    Publication Year
    2002
    ISBN/ISSN
    1471-213X
    Data From Reference
    Aberrations (2)
    Alleles (15)
    Genes (10)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (7)
    Experimental Tools (2)
    Transgenic Constructs (7)