Reference Report

Reference
Citation	González, I., Aparicio, R., Busturia, A. (2008). Functional characterization of the dRYBP gene in Drosophila. Genetics 179(3): 1373--1388. (Export to RIS)
FlyBase ID	FBrf0207353
Publication Type	Research paper
PubMed ID	18562658
PubMed Abstract	The Drosophila dRYBP gene has been described to function as a Polycomb-dependent transcriptional repressor. To determine the in vivo function of the dRYBP gene, we have generated mutations and analyzed the associated phenotypes. Homozygous null mutants die progressively throughout development and present phenotypes variable both in their penetrance and in their expressivity, including disrupted oogenesis, a disorganized pattern of the syncytial nuclear divisions, defects in pattern formation, and decreased wing size. Although dRYBP mutations do not show the homeotic-like phenotypes typical of mutations in the PcG and trxG genes, they enhance the phenotypes of mutations of either the Sex comb extra gene (PcG) or the trithorax gene (trxG). Finally, the dRYBP protein interacts physically with the Sex comb extra and the Pleiohomeotic proteins, and the homeotic-like phenotypes produced by the high levels of the dRYBP protein are mediated through its C-terminal domain. Our results indicate that the dRYBP gene functions in the control of cell identity together with the PcG/trxG proteins. Furthermore, they also indicate that dRYBP participates in the control of cell proliferation and cell differentiation and we propose that its functional requirement may well depend on the robustness of the animal.
DOI	10.1534/genetics.107.082966
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (1)
	Df(2R)58B3-59
Alleles (24)
	Pc³ Pc^{T:Avic\GFP-EGFP} pho¹ pho^cv Rpd3¹ RYBP^{dsRNA.Scer\UAS.cGa} RYBP^KG08683 RYBP^Scer\UAS.cBa RYBP^Δ16 RYBP^Δ55 RYBP^{ΔCt.Scer\UAS} RYBP^{ΔZF.Scer\UAS} Sce¹ Scer\GAL4^arm.PS Scer\GAL4^ci.PC Scer\GAL4^da.G32 Scer\GAL4^en-e16E Scer\GAL4^sd-SG29.1 Scer\GAL4^tub.PU Scer\GAL4^{Ubx-lac1-Gal4} Trl^13C Trl^R85 trx^E2 w^+mC
Constructs (11)
	P{ci-GAL4.C} P{GAL4-arm.S} P{GAL4-da.G32} P{Pc^{T:Avic\GFP-EGFP}} P{SUPor-P} P{SUPor-P-Δ16} P{tub-GAL4.U} P{UAS-RYBP.B} P{UAS-RYBP.RNAi} P{UAS-RYBP.ΔCt} P{UAS-RYBP.ΔZF}
Genes (15)
	abd-A Abd-B CycA His3 Pc pho Rpd3 RYBP Sce Scer\GAL4 Scr Trl trx Ubx w
Insertions (5)
	P{en2.4-GAL4}e16E P{GawB}sd^SG29.1 P{GawB}Ubx^lac1-GAL4 P{SUPor-P}RYBP^KG08683 P{SUPor-P-Δ16}RYBP^Δ16
Natural transposons (1)
	P-element