Reference Report

Reference
Citation	Chlamydas, S., Heun, P., Dimitri, P., Moschetti, R., Barsanti, P., Caizzi, R. (2009). The paracentric inversion In(2Rh)PL alters the centromeric organization of chromosome 2 in Drosophila melanogaster. Chromosome Res. 17(1): 1--9. (Export to RIS)
FlyBase ID	FBrf0207586
Publication Type	Research paper
PubMed ID	19105035
PubMed Abstract	Centromeres are complex structures involved in an evolutionarily conserved function, the correct segregation of chromosomes and chromatids during meiosis and mitosis. The centromere is determined by epigenetic processes that result in a particular nucleosome organization (CEN chromatin) that differs from the rest of the chromatin including the heterochromatin that normally surrounds the centromere in higher organisms. Many of the current models of centromere origin and organization rely on the molecular and cytological characterization of minichromosomes and their derivatives, and on studies on the origin and maintenance of neocentromeres. Here, we describe the peculiar centromere organization observed in In(2Rh)PL, a paracentric D. melanogaster inversion in which the centromere is maintained in its natural context but is directly flanked by a euchromatic domain as a result of the rearrangement. We have identified the breakpoints of the inversion and show that the proximal one is within the centromere region. The data presented suggest that, notwithstanding the loss of all the pericentric 2Rh heterochromatin, the centromere of the In(2Rh)PL chromosome is still active but presents a nucleosomal organization quite different from the organization usually observed in the centromeric region.
DOI	10.1007/s10577-008-9000-3
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Chromosome Res.
Title	Chromosome Research
Publication Year	1993-
ISBN/ISSN	0967-3849
Data from Reference
Aberrations (1)
	In(2R)PL
Constructs (1)
	P{w⁺-un1}
Genes (5)
	CG4409 CG7848 cid His3 Rsp
Insertions (1)
	P{w⁺-un1}PL
Natural transposons (2)
	Bari1 P-element