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Citation
Shelly, S., Lukinova, N., Bambina, S., Berman, A., Cherry, S. (2009). Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus.  Immunity 30(4): 588--598.
FlyBase ID
FBrf0207677
Publication Type
Research paper
Abstract

Intrinsic innate immune mechanisms are the first line of defense against pathogens and exist to control infection autonomously in infected cells. Here, we showed that autophagy, an intrinsic mechanism that can degrade cytoplasmic components, played a direct antiviral role against the mammalian viral pathogen vesicular stomatitis virus (VSV) in the model organism Drosophila. We found that the surface glycoprotein, VSV-G, was likely the pathogen-associated molecular pattern (PAMP) that initiated this cell-autonomous response. Once activated, autophagy decreased viral replication, and repression of autophagy led to increased viral replication and pathogenesis in cells and animals. Lastly, we showed that the antiviral response was controlled by the phosphatidylinositol 3-kinase (PI3K)-Akt-signaling pathway, which normally regulates autophagy in response to nutrient availability. Altogether, these data uncover an intrinsic antiviral program that links viral recognition to the evolutionarily conserved nutrient-signaling and autophagy pathways.

PubMed ID
PubMed Central ID
PMC2754303 (PMC) (EuropePMC)
Related Publication(s)
Note

Strange bedfellows expose ancient secrets of autophagy in immunity.
Deretic, 2009, Immunity 30(4): 479--481 [FBrf0207820]

VSV infection is sensed by Drosophila, attenuates nutrient signaling, and thereby activates antiviral autophagy.
Cherry, 2009, Autophagy 5(7): 1062--1063 [FBrf0209053]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Immunity
    Title
    Immunity
    Publication Year
    1994-
    ISBN/ISSN
    1074-7613
    Data From Reference