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Citation
Roegiers, F., Kavaler, J., Tolwinski, N., Chou, Y.T., Duan, H., Bejarano, F., Zitserman, D., Lai, E.C. (2009). Frequent Unanticipated Alleles of lethal giant larvae in Drosophila Second Chromosome Stocks.  Genetics 182(1): 407--410.
FlyBase ID
FBrf0207678
Publication Type
Research paper
Abstract

Forty years ago, a high frequency of lethal giant larvae (lgl) alleles in wild populations of Drosophila melanogaster was reported. This locus has been intensively studied for its roles in epithelial polarity, asymmetric neural divisions, and restriction of tissue proliferation. Here, we identify a high frequency of lgl alleles in the Bloomington second chromosome deficiency kit and the University of California at Los Angeles Bruinfly FRT40A-lethal P collection. These unrecognized aberrations confound the use of these workhorse collections for phenotypic screening or genetic mapping. In addition, we determined that independent alleles of insensitive, reported to affect asymmetric cell divisions during sensory organ development, carry lgl deletions that are responsible for the observed phenotypes. Taken together, these results encourage the routine testing of second chromosome stocks for second-site alleles of lgl.

PubMed ID
PubMed Central ID
PMC2674838 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Aberrations (13)
    Alleles (7)
    Genes (7)
    Natural transposons (1)
    Experimental Tools (2)
    Transgenic Constructs (1)