Reference Report

Reference
Citation	Donlea, J.M., Ramanan, N., Shaw, P.J. (2009). Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science 324(5923): 105--108. (Export to RIS)
FlyBase ID	FBrf0207700
Publication Type	Research paper
PubMed ID	19342592
PubMed Abstract	Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry is uniquely positioned to coordinate interactions between processes underlying memory and sleep need. Flies increase sleep both after exposure to an enriched social environment and after protocols that induce long-term memory. We found that flies mutant for rutabaga, period, and blistered were deficient for experience-dependent increases in sleep. Rescue of each of these genes within the ventral lateral neurons (LNVs) restores increased sleep after social enrichment. Social experiences that induce increased sleep were associated with an increase in the number of synaptic terminals in the LNV projections into the medulla. The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation.
DOI	10.1126/science.1166657
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Aberrations (1)
	In(2LR)Px⁴
Alleles (48)
	Avic\GFP^E.Scer\UAS bs² bs³ bs¹³⁴⁸ bs^Scer\UAS.cHa btl::Egfr^{Scer\UAS.T:λ\cI-DD} dlg1^{Scer\UAS.T:Avic\GFP} Egfr^DN.Scer\UAS per⁰¹ per^+t7.2 rut²⁰⁸⁰ rut^Scer\UAS.cZa Scer\GAL4^30Y Scer\GAL4^50y Scer\GAL4^104Y Scer\GAL4^121Y Scer\GAL4^154Y Scer\GAL4^210Y Scer\GAL4¹⁴⁷¹ Scer\GAL4^Aph-4-c232 Scer\GAL4^bs-1348 Scer\GAL4^c205 Scer\GAL4^c309 Scer\GAL4^c316 Scer\GAL4^c687 Scer\GAL4^c739 Scer\GAL4^c747 Scer\GAL4^c767 Scer\GAL4^dimm-929 Scer\GAL4^{elav.Switch.PO} Scer\GAL4^ey-OK107 Scer\GAL4^Mef2.247 Scer\GAL4^Mz19 Scer\GAL4^Mz520 Scer\GAL4^Mz671 Scer\GAL4^Mz717 Scer\GAL4^NP0010 Scer\GAL4^NP0225 Scer\GAL4^NP1004 Scer\GAL4^NP2320 Scer\GAL4^NP3529 Scer\GAL4^NP5103 Scer\GAL4^NP5194 Scer\GAL4^NP5221 Scer\GAL4^NP6510 Scer\GAL4^P2.4.Pdf Scer\GAL4^Tab2-201Y Scer\GAL80^cry.PS
Constructs (11)
	P{cry-GAL80.S} P{elav-Switch.O} P{Mef2-GAL4.247} P{Pdf-GAL4.P2.4} P{perC7.2} P{UAS-bs.H} P{UAS-EGFP} P{UAS-eGFP-dlg1-S48S} P{UAS-Egfr.DN} P{UAS-Egfr.λtop} P{UAS-rut.Z}
Genes (10)
	Avic\GFP bs btl::Egfr dlg1 Egfr Pdf per rut Scer\GAL4 Scer\GAL80
Insertions (33)
	P{GAL4}154Y P{GAL4}bs¹³⁴⁸ P{GAL4}c687 P{GawB}30Y P{GawB}50y P{GawB}104y P{GawB}121Y P{GawB}210Y P{GawB}1471 P{GawB}Aph-4^c232 P{GawB}c205 P{GawB}c309 P{GawB}c316 P{GawB}c747 P{GawB}c767 P{GawB}CG1358^NP5221 P{GawB}dimm⁹²⁹ P{GawB}ey^OK107 P{GawB}Hr39^c739 P{GawB}Mz19 P{GawB}Mz520 P{GawB}Mz671 P{GawB}Mz717 P{GawB}NP0010 P{GawB}NP0225 P{GawB}NP1004 P{GawB}NP2320 P{GawB}NP3529 P{GawB}NP5194 P{GawB}NP6510 P{GawB}Tab2^201Y P{GawB}trol^NP5103 P{lArB}rut²⁰⁸⁰