Reference Report

Reference
Citation	Li, X., Cassidy, J.J., Reinke, C.A., Fischboeck, S., Carthew, R.W. (2009). A microRNA imparts robustness against environmental fluctuation during development. Cell 137(2): 273--282. (Export to RIS)
FlyBase ID	FBrf0207846
Publication Type	Research paper
PubMed ID	19379693
PubMed Abstract	The microRNA miR-7 is perfectly conserved from annelids to humans, and yet some of the genes that it regulates in Drosophila are not regulated in mammals. We have explored the role of lineage restricted targets, using Drosophila, in order to better understand the evolutionary significance of microRNA-target relationships. From studies of two well characterized developmental regulatory networks, we find that miR-7 functions in several interlocking feedback and feedforward loops, and propose that its role in these networks is to buffer them against perturbation. To directly demonstrate this function for miR-7, we subjected the networks to temperature fluctuation and found that miR-7 is essential for the maintenance of regulatory stability under conditions of environmental flux. We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks.
DOI	10.1016/j.cell.2009.01.058
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(2R)exu1
Alleles (23)
	aop^yan-1 ato^Scer\UAS.cJa Avic\GFP^{hs.Stinger.T:nls-tra} Avic\GFP^{mir-7.T:nls-tra} Avic\GFP^{-Prn.mir-7.T:nls-tra} btl::Egfr^{Scer\UAS.T:λ\cI-DD} E(spl)m7-HLH^{Scer\UAS.cdCa} E(spl)m8-HLH^Scer\UAS.cTa E(spl)mδ-HLH^{Scer\UAS.cdCa} Egfr^DN.Scer\UAS gypsy\su(Hw)BR⁴³⁰ mir-7^Scer\UAS.cLb mir-7^{Scer\UAS.T:Disc\RFP-DsRed2} mir-7^Δ1 N^ts3 pnt^P1.Scer\UAS sc^Scer\UAS.cHa Scer\GAL4^dpp.blk1 Scer\GAL4^GMR.PF Scer\GAL4^ptc-559.1 ttk^p69.Scer\UAS ttk^p88.Scer\UAS w^+mC
Constructs (16)
	P{GAL4-dpp.blk1} P{GAL4-ninaE.GMR} P{mir-7-GFP.L} P{mir-7-GFP.-Prn} P{UAS-ato.J} P{UAS-DsRed2-mir-7} P{UAS-E(spl).T} P{UAS-Egfr.DN} P{UAS-Egfr.λtop} P{UAS-HLHm7.C} P{UAS-mir-7.L} P{UAS-mδ} P{UAS-pnt.P1} P{UAS-sc.USC} P{UAS-ttk.p69} P{UAS-ttk.p88}
Genes (22)
	aop ato Avic\GFP btl::Egfr da Dcr-1 E(spl)m7-HLH E(spl)m8-HLH E(spl)mδ-HLH Egfr elav gypsy\su(Hw)BR mir-7 N pnt sc Scer\GAL4 sens Su(H) T:nls-tra ttk w
Insertions (1)
	P{GawB}ptc^559.1
Natural transposons (1)
	P-element