Reference Report

Reference
Citation	Mendes, C.S., Levet, C., Chatelain, G., Dourlen, P., Fouillet, A., Dichtel-Danjoy, M.L., Gambis, A., Ryoo, H.D., Steller, H., Mollereau, B. (2009). ER stress protects from retinal degeneration. EMBO J. 28(9): 1296--1307. (Export to RIS)
FlyBase ID	FBrf0207956
Publication Type	Research paper
PubMed ID	19339992
PubMed Abstract	The unfolded protein response (UPR) is a specific cellular process that allows the cell to cope with the overload of unfolded/misfolded proteins in the endoplasmic reticulum (ER). ER stress is commonly associated with degenerative pathologies, but its role in disease progression is still a matter for debate. Here, we found that mutations in the ER-resident chaperone, neither inactivation nor afterpotential A (NinaA), lead to mild ER stress, protecting photoreceptor neurons from various death stimuli in adult Drosophila. In addition, Drosophila S2 cultured cells, when pre-exposed to mild ER stress, are protected from H(2)O(2), cycloheximide- or ultraviolet-induced cell death. We show that a specific ER-mediated signal promotes antioxidant defences and inhibits caspase-dependent cell death. We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses.
DOI	10.1038/emboj.2009.76
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Alleles (22)
	Apc^Q8 Avic\GFP^Scer\UAS.cUa BacA\p35^GMR.PH Dcp-1^Scer\UAS.cPa Ecol\lacZ⁰⁶²⁷⁰ Ecol\lacZ^{Fer1HCH-00451} Ecol\lacZ^{Fer2LCH-00035} Fer1HCH⁰⁰⁴⁵¹ Fer2LCH⁰⁰⁰³⁵ Mmus\Cd8a^{Parp.Scer\UAS.T:Avic\GFP-YFP.Venus} ninaA¹ ninaA¹⁹ ninaA^E110V ninaA^G98D ninaA^R120K ninaE¹⁷ ninaE^G69D p53^Scer\UAS.cJa rpr^Scer\UAS.cZa Scer\GAL4^ninaE.PT Thor⁰⁶²⁷⁰ Xbp1^{Scer\UAS.T:Avic\GFP-EGFP}
Constructs (9)
	P{GMRP35} P{PZ} P{rh1-GAL4} P{UAS-CD8:PARP-Venus} P{UAS-Dcp-1.P} P{UAS-GFP.U} P{UAS-p53.J} P{UAS-rpr.Z} P{UAS-Xbp1.EGFP}
Genes (16)
	Apc Avic\GFP BacA\p35 Dcp-1 Ecol\lacZ Fer1HCH Fer2LCH Hsc70-3 Mmus\Cd8a ninaA ninaE p53 rpr Scer\GAL4 Thor Xbp1
Insertions (3)
	P{PZ}Fer1HCH⁰⁰⁴⁵¹ P{PZ}Fer2LCH⁰⁰⁰³⁵ P{PZ}Thor⁰⁶²⁷⁰
Natural transposons (1)
	P-element