Reference Report

Reference
Citation	Liu, Q.X., Hiramoto, M., Ueda, H., Gojobori, T., Hiromi, Y., Hirose, S. (2009). Midline governs axon pathfinding by coordinating expression of two major guidance systems. Genes Dev. 23(10): 1165--1170. (Export to RIS)
FlyBase ID	FBrf0207988
Publication Type	Research paper
PubMed ID	19451216
PubMed Abstract	Formation of the neural network requires concerted action of multiple axon guidance systems. How neurons orchestrate expression of multiple guidance genes is poorly understood. Here, we show that Drosophila T-box protein Midline controls expression of genes encoding components of two major guidance systems: Frazzled, ROBO, and Slit. In midline mutant, expression of all these molecules are reduced, resulting in severe axon guidance defects, whereas misexpression of Midline induces their expression. Midline is present on the promoter regions of these genes, indicating that Midline controls transcription directly. We propose that Midline controls axon pathfinding through coordinating the two guidance systems.
DOI	10.1101/gad.1774209
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (1)
	Df(2L)cl-h1
Alleles (15)
	Ecol\lacZ^C4.Adh Ecol\lacZ^fra.mut Ecol\lacZ^fra.PL Ecol\lacZ^{sli.4.5HH.mut} Ecol\lacZ^sli.4.5HH Ecol\lacZ^sli.mut Ecol\lacZ^sli.PL Lim3^{T:Btau\MAPT,T:Hsap\MYC} mid¹ mid² mid^D62 mid^Scer\UAS.cLa Scer\GAL4^elav-C155 Scer\GAL4^l(1)BP-1 w^+mC
Constructs (7)
	P{fra-lacZ.L} P{fra-lacZ.mut} P{Lim3.tau-myc.T} P{sli(4.5)-lacZ.mut} P{sli-lacZ.L} P{sli-lacZ.mut} P{UAS-mid.L}
Genes (10)
	Ecol\lacZ fra futsch Lim3 mid NetB robo Scer\GAL4 sli w
Insertions (2)
	P{GawB}elav^C155 P{GawB}l(1)BP¹
Natural transposons (1)
	P-element