Open Close
Reference
Citation
Fang, M., Ren, H., Liu, J., Cadigan, K.M., Patel, S.R., Dressler, G.R. (2009). Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways.  Development 136(11): 1929--1938.
FlyBase ID
FBrf0207992
Publication Type
Research paper
Abstract
Development of the fruit fly Drosophila depends in part on epigenetic regulation carried out by the concerted actions of the Polycomb and Trithorax group of proteins, many of which are associated with histone methyltransferase activity. Mouse PTIP is part of a histone H3K4 methyltransferase complex and contains six BRCT domains and a glutamine-rich region. In this article, we describe an essential role for the Drosophila ortholog of the mammalian Ptip (Paxip1) gene in early development and imaginal disc patterning. Both maternal and zygotic ptip are required for segmentation and axis patterning during larval development. Loss of ptip results in a decrease in global levels of H3K4 methylation and an increase in the levels of H3K27 methylation. In cell culture, Drosophila ptip is required to activate homeotic gene expression in response to the derepression of Polycomb group genes. Activation of developmental genes is coincident with PTIP protein binding to promoter sequences and increased H3K4 trimethylation. These data suggest a highly conserved function for ptip in epigenetic control of development and differentiation.
PubMed ID
PubMed Central ID
PMC2680114 (PMC) (EuropePMC)
Related Publication(s)
Erratum
Corrigendum.
Fang et al., 2009, Development 136(13): 2309 [FBrf0208341]
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (2)
    Alleles (3)
    Genes (32)
    Cell Lines (1)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (2)