Reference Report

Reference
Citation	Gruenewald, C., Botella, J.A., Bayersdorfer, F., Navarro, J.A., Schneuwly, S. (2009). Hyperoxia-induced neurodegeneration as a tool to identify neuroprotective genes in Drosophila melanogaster. Free Radical Biol. Med. 46(12): 1668--1676. (Export to RIS)
FlyBase ID	FBrf0208024
Publication Type	Research paper
PubMed ID	19345730
PubMed Abstract	Oxidative stress has been reported to be a common underlying mechanism in the pathogenesis of many neurodegenerative disorders such as Alzheimer, Huntington, Creutzfeld-Jakob, and Parkinson disease. Despite the increasing number of articles showing a correlation between oxidative damage and neurodegeneration little is known about the genetic elements that confer protection against the deleterious effects of an oxidative imbalance in neurons. We show that oxygen-induced damage is a direct cause of brain degeneration in Drosophila and establish an experimental setup measuring dopaminergic neuron survival to model oxidative stress-induced neurodegeneration in flies. The overexpression of superoxide dismutase but not catalase was able to protect dopaminergic neurons against oxidative imbalance under hyperoxia treatment. In an effort to identify new genes involved in the process of oxidative stress-induced neurodegeneration, we have carried out a genome-wide expression analysis to identify genes whose expression is upregulated in fly heads under hyperoxia. Among them, a number of mitochondrial and cytoplasmic chaperones could be identified and were shown to protect dopaminergic neurons when overexpressed, thus validating our approach to identifying new genes involved in the neuronal defense mechanism against oxidative stress.
DOI	10.1016/j.freeradbiomed.2009.03.025
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Free Radical Biol. Med.
Title	Free Radical Biology and Medicine
Publication Year	1987-
ISBN/ISSN	0891-5849
Data from Reference
Alleles (8)
	Avic\GFP^{Stinger.Scer\UAS.T:nls-tra} Cat^Scer\UAS.cAa Hsap\SOD1^Scer\UAS.cPa Hsc70-3^Scer\UAS.cEa Hsc70-4^Scer\UAS.cEa Hsp22^EP3247 Scer\GAL4^Act.PU Scer\GAL4^ple.PF
Constructs (7)
	P{Act-GAL4.U} P{ple-GAL4.F} P{UAS-Cat.A} P{UAS-Hsap\SOD1.P} P{UAS-Hsc70-3.WT} P{UAS-Hsc70-4.WT} P{UAS-Stinger}
Genes (79)
	Aats-asp ade2 ade3 ade5 Ahcy13 Arc2 Avic\GFP borr Cat CG1882 CG2017 CG2064 CG2909 CG3008 CG3011 CG3397 CG3476 CG3590 CG5955 CG5999 CG6272 CG6512 CG6767 CG7130 CG8112 CG9547 CG10420 CG10638 CG10916 CG11089 CG11796 CG11825 CG12171 CG12264 CG12868 CG13659 CG14906 CG15661 CG15784 CG16898 CG17327 CG18522 Cyp4e3 Cyp6d2 Cyp12c1 Cyp309a1 Cyp309a2 Dgp-1 eIF-2β escl Fer1HCH Fer2LCH glob1 GstD3 GstD9 GstE1 GstE7 GstE8 Hsap\SOD1 Hsc70-3 Hsc70-4 Hsp22 Hsp70Bc ImpL3 l(3)02640 MtnA Nmdmc P32 pug RpA-70 Scer\GAL4 Shawn sni Sod su(r) Tsp42Ed Tyler vir-1 Xrp1
Insertions (1)
	P{EP}Hsp67Bb^EP3247