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Citation
Babcock, D.T., Landry, C., Galko, M.J. (2009). Cytokine Signaling Mediates UV-Induced Nociceptive Sensitization in Drosophila Larvae.  Curr. Biol. 19(10): 799--806.
FlyBase ID
FBrf0208032
Publication Type
Research paper
Abstract

Heightened nociceptive (pain) sensitivity is an adaptive response to tissue damage and serves to protect the site of injury. Multiple mediators of nociceptive sensitization have been identified in vertebrates, but the complexity of the vertebrate nervous system and tissue-repair responses has hindered identification of the precise roles of these factors.Here we establish a new model of nociceptive sensitization in Drosophila larvae, in which UV-induced tissue damage alters an aversive withdrawal behavior. We find that UV-treated larvae develop both thermal hyperalgesia, manifested as an exaggerated response to noxious thermal stimuli, and thermal allodynia, a responsiveness to subthreshold thermal stimuli that are not normally perceived as noxious. Allodynia is dependent upon a tumor necrosis factor (TNF) homolog, Eiger, released from apoptotic epidermal cells, and the TNF receptor, Wengen, expressed on nociceptive sensory neurons.These results demonstrate that cytokine-mediated nociceptive sensitization is conserved across animal phyla and set the stage for a sophisticated genetic dissection of the cellular and molecular alterations responsible for development of nociceptive sensitization in sensory neurons.

PubMed ID
PubMed Central ID
PMC4017352 (PMC) (EuropePMC)
Related Publication(s)
Research paper

Two sides of the same coin no longer: Genetic separation of nociceptive sensitization responses.
Babcock and Galko, 2009, Commun. Integr. Biol. 2(6): 517--519 [FBrf0210113]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference
    Genes (6)