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Citation
Ismail, A.M., Padrick, S.B., Chen, B., Umetani, J., Rosen, M.K. (2009). The WAVE regulatory complex is inhibited.  Nat. Struct. Mol. Biol. 16(5): 561--563.
FlyBase ID
FBrf0208042
Publication Type
Research paper
Abstract

The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.

PubMed ID
PubMed Central ID
PMC2716658 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Struct. Mol. Biol.
    Title
    Nature Structural and Molecular Biology
    Publication Year
    2004-
    ISBN/ISSN
    1545-9993 1545-9985
    Data From Reference
    Gene Groups (1)
    Genes (5)
    Physical Interactions (4)