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Citation
Gambetta, M.C., Oktaba, K., Müller, J. (2009). Essential role of the glycosyltransferase sxc/Ogt in polycomb repression.  Science 325(5936): 93--96.
FlyBase ID
FBrf0208162
Publication Type
Research paper
Abstract
Polycomb group proteins are conserved transcriptional repressors that control animal and plant development. Here, we found that the Drosophila Polycomb group gene super sex combs (sxc) encodes Ogt, the highly conserved glycosyltransferase that catalyzes the addition of N-acetylglucosamine (GlcNAc) to proteins in animals and plants. Genome-wide profiling in Drosophila revealed that GlcNAc-modified proteins are highly enriched at Polycomb response elements. Among different Polycomb group proteins, Polyhomeotic is glycosylated by Sxc/Ogt in vivo. sxc/Ogt-null mutants lacked O-linked GlcNAcylation and failed to maintain Polycomb transcriptional repression even though Polycomb group protein complexes were bound at their target sites. Polycomb repression appears to be a critical function of Sxc/Ogt in Drosophila and may be mediated by the glycosylation of Polyhomeotic.
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Related Publication(s)
Note
Transcription. Sweet silencing.
Simon, 2009, Science 325(5936): 45--46 [FBrf0215090]
A little bit of sugar makes polycomb better.
Schwartz and Pirrotta, 2009, J. Mol. Cell. Biol. 1(1): 11--12 [FBrf0215114]
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Alleles (7)
    Genes (23)