Reference Report

Reference
Citation	Corl, A.B., Berger, K.H., Ophir-Shohat, G., Gesch, J., Simms, J.A., Bartlett, S.E., Heberlein, U. (2009). Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell 137(5): 949--960. (Export to RIS)
FlyBase ID	FBrf0208186
Publication Type	Research paper
PubMed ID	19464045
PubMed Abstract	The consequences of alcohol use disorders (AUDs) are devastating to individuals and society, yet few treatments are currently available. To identify genes regulating the behavioral effects of ethanol, we conducted a genetic screen in Drosophila and identified a mutant, happyhour (hppy), due to its increased resistance to the sedative effects of ethanol. Hppy protein shows strong homology to mammalian Ste20 family kinases of the GCK-1 subfamily. Genetic and biochemical experiments revealed that the epidermal growth factor (EGF)-signaling pathway regulates ethanol sensitivity in Drosophila and that Hppy functions as an inhibitor of the pathway. Acute pharmacological inhibition of the EGF receptor (EGFR) in adult animals altered acute ethanol sensitivity in both flies and mice and reduced ethanol consumption in a preclinical rat model of alcoholism. Inhibitors of the EGFR or components of its signaling pathway are thus potential pharmacotherapies for AUDs.
DOI	10.1016/j.cell.2009.03.020
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (23)
	aop^ACT.Scer\UAS aop^Scer\UAS.cRa Avic\GFP^Scer\UAS.cUa Egfr^DN.Scer\UAS Egfr^GD1654 Egfr^Scer\UAS.cBa hppy^17-51 hppy^exc3 hppy^exc16 hppy^KG05537 hppy^RB.Scer\UAS rho^iks rl^{Sem.C.Scer\UAS} S^d01624 Scer\GAL4^elav.PLu Scer\GAL4^elav-C155 Scer\GAL4^GMR.PF Scer\GAL4^hppy-17-51 Scer\GAL4^Ilp2.PR Scer\GAL4^ple.PF Scer\GAL4^tub.PU spi^{sec.Scer\UAS.P\T} w^+mC
Constructs (15)
	P{GAL4-elav.L} P{GAL4-ninaE.GMR} P{GawB} P{GD1654} P{Ilp2-GAL4.R} P{ple-GAL4.F} P{tub-GAL4.U} P{UAS-aop.ACT} P{UAS-aop.WT} P{UAS-Egfr.B} P{UAS-Egfr.DN} P{UAS-GFP.U} P{UAS-hppy.RB} P{UASp-spi.sec} P{UAS-rl^Sem}
Genes (13)
	aop Avic\GFP bsk Egfr hep hppy Jra rho rl S Scer\GAL4 spi w
Insertions (5)
	P{GawB}elav^C155 P{GawB}hppy^17-51 P{SUPor-P}hppy^KG05537 P{UAS-hppy.RB}1 P{UAS-hppy.RB}2
Natural transposons (1)
	P-element