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Citation
Corl, A.B., Berger, K.H., Ophir-Shohat, G., Gesch, J., Simms, J.A., Bartlett, S.E., Heberlein, U. (2009). Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors.  Cell 137(5): 949--960.
FlyBase ID
FBrf0208186
Publication Type
Research paper
Abstract

The consequences of alcohol use disorders (AUDs) are devastating to individuals and society, yet few treatments are currently available. To identify genes regulating the behavioral effects of ethanol, we conducted a genetic screen in Drosophila and identified a mutant, happyhour (hppy), due to its increased resistance to the sedative effects of ethanol. Hppy protein shows strong homology to mammalian Ste20 family kinases of the GCK-1 subfamily. Genetic and biochemical experiments revealed that the epidermal growth factor (EGF)-signaling pathway regulates ethanol sensitivity in Drosophila and that Hppy functions as an inhibitor of the pathway. Acute pharmacological inhibition of the EGF receptor (EGFR) in adult animals altered acute ethanol sensitivity in both flies and mice and reduced ethanol consumption in a preclinical rat model of alcoholism. Inhibitors of the EGFR or components of its signaling pathway are thus potential pharmacotherapies for AUDs.

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Related Publication(s)
Note

With Happyhour, everyone's under the table.
Palfreyman, 2009, Cell 137(5): 802--804 [FBrf0208260]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference