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Smith-Bolton, R.K., Worley, M.I., Kanda, H., Hariharan, I.K. (2009). Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc.  Dev. Cell 16(6): 797--809.
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Research paper

The study of regeneration would be aided greatly by systems that support large-scale genetic screens. Here we describe a nonsurgical method for inducing tissue damage and regeneration in Drosophila larvae by inducing apoptosis in the wing imaginal disc in a spatially and temporally regulated manner. Tissue damage results in localized regenerative proliferation characterized by altered expression of patterning genes and growth regulators as well as a temporary loss of markers of cell fate commitment. Wingless and Myc are induced by tissue damage and are important for regenerative growth. Furthermore, ectopic Myc enhances regeneration when other growth drivers tested do not. As the animal matures, the ability to regenerate is lost and cannot be restored by activation of Wingless or Myc. This system is conducive to forward genetic screens, enabling an unbiased search for genes that regulate both the extent of and the capacity for regeneration.

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PubMed Central ID
PMC2705171 (PMC) (EuropePMC)
Related Publication(s)

Genetic DISC-section of regeneration in Drosophila.
Nachtrab and Poss, 2009, Dev. Cell 16(6): 777--778 [FBrf0208271]

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    Parent Publication
    Publication Type
    Dev. Cell
    Developmental Cell
    Publication Year
    1534-5807 1878-1551
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    Genes (19)