Reference Report

Reference
Citation	Jacques, C., Soustelle, L., Nagy, I., Diebold, C., Giangrande, A. (2009). A novel role of the glial fate determinant glial cells missing in hematopoiesis. Int. J. Dev. Biol. 53(7): 1013--1022. (Export to RIS)
FlyBase ID	FBrf0208351
Publication Type	Research paper
PubMed ID	19598118
PubMed Abstract	Glial cell deficient/Glial cells missing (Glide/Gcm) transcription factor is expressed in all glial precursors of the Drosophila embryo. Gcm is necessary and sufficient to induce glial differentiation but also plays a role in other cell types, by interacting with specific factors. To find potential partners of Gcm which trigger these other pathways, we performed a yeast two-hybrid screen and identified dpias, a gene involved in post-embryonic hematopoiesis. dpias larvae show melanotic tumors due to excess of lamellocytes, a hemocyte lineage that is involved in non-self recognition. We here show that blocking Gcm activity also triggers melanotic tumors and that gcm interacts genetically with dpias. Moreover, the members of the Janus Kinase (JAK)/ Signal Transducer and Activator of Transcription (STAT) pathway, which are known for their role in the vertebrate and invertebrate immune system and are required for dpias-dependent tumor formation, act downstream of Gcm. Altogether, this study identifies an unpredicted role of Gcm, dictated by its cofactor dpias, allowing Gcm to act in a specific pathway. Together with the recent finding that glia act as scavengers during development and in pathological conditions, our data open new perspectives onto the cellular and molecular pathways involved in non-self recognition within and outside the nervous system.
DOI	10.1387/ijdb.082726cj
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Int. J. Dev. Biol.
Title	International Journal of Developmental Biology
Publication Year	1989-
ISBN/ISSN	0214-6282
Data from Reference
Alleles (24)
	Avic\GFP^{E.Scer\UAS.cMa} dome^GD14494 Ecol\lacZ^gcm-rA87 gcm²⁶ gcm^{DN.Scer\UAS.T:Rep-en} gcm^{N7-4.DN.Scer\UAS.T:Rep-en} gcm^rA87.P hop² hop^GD9157 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} os^GD1158 Scer\GAL4^Cg.PA Scer\GAL4^dome-PG14 Scer\GAL4^gcm-rA87.P Scer\GAL4^He.PZ Scer\GAL4^Hml.PG Scer\GAL4^lz-gal4 Scer\GAL4^ppl.PP Scer\GAL4^Ser.PBS Scer\GAL4^srp.D.cCa Scer\GAL80^ts.αTub84B Stat92E^GD4492 Su(var)2-10¹ upd3^GD6811
Constructs (12)
	P{Cg-GAL4.A} P{GD1158} P{He-GAL4.Z} P{Hml-GAL4.G} P{ppl-GAL4.P} P{Ser-GAL4.BS} P{srpD-GAL4.C} P{tubP-GAL80^ts} P{UAS-EGFP.M} P{UAS-gcm.DN} P{UAS-gcm.N7-4.DN} P{UAS-mCD8::GFP.L}
Genes (31)
	Avic\GFP CG2199 CG2926 CG9715 chn dome Ecol\lacZ gcm gcm2 He Hml hop Kap-α1 lz MEP-1 Mical Mmus\Cd8a os Pen phol ppl Pxn Scer\GAL4 Scer\GAL80 Ser slik srp Stat92E Su(var)2-10 Uba2 upd3
Insertions (4)
	P{GawB}dome^PG14 P{GawB}gcm^rA87.P P{GawB}lz^gal4 P{PZ}gcm^rA87