Reference Report

Reference
Citation	Mao, Z., Davis, R.L. (2009). Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity. Front. Neural Circuits 3(): 5. (Export to RIS)
FlyBase ID	FBrf0208427
Publication Type	Research paper
PubMed ID	19597562
PubMed Abstract	We examined tyrosine hydroxylase (TH-GAL4) expression and anti-TH immunoreactivity in the Drosophila protocerebrum and characterized single cell clones of the TH-GAL4 neurons. Eight clusters of putative dopaminergic neurons were characterized. Neurons in three of the clusters project to the mushroom body neuropil: PAM neurons project to the medial portion of the horizontal lobes; PPL1 neurons project to the vertical lobes, the junction area, the heel and distal peduncle; and PPL2ab neurons project to the calyx. Five types of PPL1 neurons were discovered that innervate different zones of the mushroom body lobes. Functional imaging experiments showed that the dopaminergic processes in four of the zones differ in response properties to odor, electric shock, or following the pairing of odor and electric shock. These results indicate that distinct dopaminergic neurons define separate zones of the mushroom body lobes and are probably involved in different functions. Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes.
DOI	10.3389/neuro.04.005.2009
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Front. Neural Circuits
Title	Frontiers in neural circuits
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ISBN/ISSN	1662-5110
Data from Reference
Alleles (11)
	Avic\GFP^{GCaMP1.3.Scer\UAS.cUa} Avic\GFP^{Scer\UAS.T:Ecol\lacZ,T:SV40\nls2} Mmus\Cd8a^{Scer\FRT.Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.S.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^c305a Scer\GAL4^c739 Scer\GAL4^ey-OK107 Scer\GAL4^NP1131 Scer\GAL4^ple.PF Syt1^{Scer\UAS.T:Avic\GFP-EGFP}
Constructs (7)
	P{ple-GAL4.F} P{UAS(FRT.CD2.y⁺)CD8-GFP} P{UAS(-FRT)CD8-GFP} P{UAS-GCaMP1.3.U} P{UAS-GFP::lacZ.nls} P{UAS-mCD8::GFP.L} P{UAS-syt.eGFP}
Genes (7)
	Avic\GFP brp Fas2 Mmus\Cd8a ple Scer\GAL4 Syt1
Insertions (4)
	P{GawB}c305a P{GawB}ey^OK107 P{GawB}Hr39^c739 P{GawB}NP1131
Transcripts (4)
	Scer\GAL4^c305aRA Scer\GAL4^c739RA Scer\GAL4^NP1131RA Scer\GAL4^ple.PFRA