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Citation
Cronin, S.J., Nehme, N.T., Limmer, S., Liegeois, S., Pospisilik, J.A., Schramek, D., Leibbrandt, A., Simoes, R.M., Gruber, S., Puc, U., Ebersberger, I., Zoranovic, T., Neely, G.G., von Haeseler, A., Ferrandon, D., Penninger, J.M. (2009). Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection.  Science 325(5938): 340--343.
FlyBase ID
FBrf0208489
Publication Type
Research paper
Abstract
Innate immunity represents the first line of defense in animals. We report a genome-wide in vivo Drosophila RNA interference screen to uncover genes involved in susceptibility or resistance to intestinal infection with the bacterium Serratia marcescens. We first employed whole-organism gene suppression, followed by tissue-specific silencing in gut epithelium or hemocytes to identify several hundred genes involved in intestinal antibacterial immunity. Among the pathways identified, we showed that the JAK-STAT signaling pathway controls host defense in the gut by regulating stem cell proliferation and thus epithelial cell homeostasis. Therefore, we revealed multiple genes involved in antibacterial defense and the regulation of innate immunity.
PubMed ID
PubMed Central ID
PMC2975362 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference