Reference Report

Reference
Citation	Wolfstetter, G., Shirinian, M., Stute, C., Grabbe, C., Hummel, T., Baumgartner, S., Palmer, R.H., Holz, A. (2009). Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm. Mech. Dev. 126(8-9): 721--736. (Export to RIS)
FlyBase ID	FBrf0208570
Publication Type	Research paper
PubMed ID	19463947
PubMed Abstract	In this study we describe the morphological and genetic analysis of the Drosophila mutant gürtelchen (gurt). gurt was identified by screening an EMS collection for novel mutations affecting visceral mesoderm development and was named after the distinct belt shaped visceral phenotype. Interestingly, determination of visceral cell identities and subsequent visceral myoblast fusion is not affected in mutant embryos indicating a later defect in visceral development. gurt is in fact a new huckebein (hkb) allele and as such exhibits nearly complete loss of endodermal derived structures. Targeted ablation of the endodermal primordia produces a phenotype that resembles the visceral defects observed in huckebein(gürtelchen) (hkb(gurt)) mutant embryos. It was shown previously that visceral mesoderm development requires complex interactions between visceral myoblasts and adjacent tissues. Signals from the neighbouring somatic myoblasts play an important role in cell type determination and are a prerequisite for visceral muscle fusion. Furthermore, the visceral mesoderm is known to influence endodermal migration and midgut epithelium formation. Our analyses of the visceral phenotype of hkb(gurt) mutant embryos reveal that the adjacent endoderm plays a critical role in the later stages of visceral muscle development, and is required for visceral muscle elongation and outgrowth after proper myoblast fusion.
DOI	10.1016/j.mod.2009.05.001
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Df(3L)vin7
Alleles (18)
	Ecol\lacZ^brk-X47 Ecol\lacZ^croc.7 Ecol\lacZ^kirre-rP298 Ecol\lacZ^Scer\UAS.cBa fkh⁶ hkb² hkb^gurt jeb^Scer\UAS.cVa jeb^weli knod^3B1-038 mbc^C1 Moe^{GMA.Scer\UAS.T:Avic\GFP-S65T} Rcom\RA^Scer\UAS.cSa Scer\GAL4^48Y Scer\GAL4^bap.3 Scer\GAL4^miple2.PW srp³ tll¹
Constructs (7)
	P{bap-GAL4.3} P{croc-lacZ.7} P{miple2-GAL4.W} P{UAS-GMA} P{UAS-jeb.V} P{UAS-lacZ.B} P{UAS-RA}
Genes (22)
	Alk bap brk byn croc Ecol\lacZ Fas2 Fas3 fkh hkb hts jeb knod mbc Moe pros Rcom\RA Scer\GAL4 srp tll Vrp1 βTub60D
Insertions (3)
	P{GawB}48Y P{PZ}rP298 P{PZ}X47
Natural transposons (1)
	P-element