Open Close
Reference
Citation
Al-Anzi, B., Sapin, V., Waters, C., Zinn, K., Wyman, R.J., Benzer, S. (2009). Obesity-blocking neurons in Drosophila.  Neuron 63(3): 329--341.
FlyBase ID
FBrf0208571
Publication Type
Research paper
Abstract

In mammals, fat store levels are communicated by leptin and insulin signaling to brain centers that regulate food intake and metabolism. By using transgenic manipulation of neural activity, we report the isolation of two distinct neuronal populations in flies that perform a similar function, the c673a-Gal4 and fruitless-Gal4 neurons. When either of these neuronal groups is silenced, fat store levels increase. This change is mediated through an increase in food intake and altered metabolism in c673a-Gal4-silenced flies, while silencing fruitless-Gal4 neurons alters only metabolism. Hyperactivation of either neuronal group causes depletion of fat stores by increasing metabolic rate and decreasing fatty acid synthesis. Altering the activities of these neurons causes changes in expression of genes known to regulate fat utilization. Our results show that the fly brain measures fat store levels and can induce changes in food intake and metabolism to maintain them within normal limits.

PubMed ID
PubMed Central ID
PMC2742587 (PMC) (EuropePMC)
Related Publication(s)
Note

Too fat to fly? New brain circuits regulate obesity in Drosophila.
Kaun and Heberlein, 2009, Neuron 63(3): 279--281 [FBrf0208594]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference