Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Blum, A.L., Li, W., Cressy, M., Dubnau, J. (2009). Short- and long-term memory in Drosophila require cAMP signaling in distinct neuron types. Curr. Biol. 19(16): 1341--1350. (Export to RIS) | ||
| FlyBase ID | FBrf0208576 | ||
| Publication Type | Research paper | ||
| PubMed ID | 19646879 | ||
| PubMed Abstract | A common feature of memory and its underlying synaptic plasticity is that each can be dissected into short-lived forms involving modification or trafficking of existing proteins and long-term forms that require new gene expression. An underlying assumption of this cellular view of memory consolidation is that these different mechanisms occur within a single neuron. At the neuroanatomical level, however, different temporal stages of memory can engage distinct neural circuits, a notion that has not been conceptually integrated with the cellular view.Here, we investigated this issue in the context of aversive Pavlovian olfactory memory in Drosophila. Previous studies have demonstrated a central role for cAMP signaling in the mushroom body (MB). The Ca(2+)-responsive adenylyl cyclase RUTABAGA is believed to be a coincidence detector in gamma neurons, one of the three principle classes of MB Kenyon cells. We were able to separately restore short-term or long-term memory to a rutabaga mutant with expression of rutabaga in different subsets of MB neurons.Our findings suggest a model in which the learning experience initiates two parallel associations: a short-lived trace in MB gamma neurons, and a long-lived trace in alpha/beta neurons. | ||
| DOI | 10.1016/j.cub.2009.07.016 | ||
| Related Publication(s) | |||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| Also Published As | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Curr. Biol. | ||
| Title | Current Biology | ||
| Publication Year | 1991- | ||
| ISBN/ISSN | 0960-9822 | ||
|
Data from Reference
|
|||
| Alleles (11)
|
|||
| Constructs (3)
|
|||
| Genes (3)
|
|||
| Insertions (6)
|
|||