Open Close
Reference
Citation
Gelbart, M.E., Larschan, E., Peng, S., Park, P.J., Kuroda, M.I. (2009). Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation.  Nat. Struct. Mol. Biol. 16(8): 825--832.
FlyBase ID
FBrf0208599
Publication Type
Research paper
Abstract
The Drosophila melanogaster male-specific lethal (MSL) complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that approximately 25% of transcribed genes on the X chromosome do not stably recruit MSL complex. Here we find that almost all active genes on the X chromosome are associated with robust H4 Lys16 acetylation (H4K16ac), the histone modification catalyzed by the MSL complex. The distribution of H4K16ac is much broader than that of the MSL complex, and our results favor the idea that chromosome-wide H4K16ac reflects transient association of the MSL complex, occurring through spreading or chromosomal looping. Our results parallel those of localized Polycomb repressive complex and its more broadly distributed chromatin mark, trimethylated histone H3 Lys27 (H3K27me3), suggesting a common principle for the establishment of active and silenced chromatin domains.
PubMed ID
PubMed Central ID
PMC2722042 (PMC) (EuropePMC)
Related Publication(s)
Note
Hit and run: X marks the spot!
Weake and Workman, 2009, Nat. Struct. Mol. Biol. 16(8): 801--803 [FBrf0215161]
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Struct. Mol. Biol.
    Title
    Nature Structural and Molecular Biology
    Publication Year
    2004-
    ISBN/ISSN
    1545-9993 1545-9985
    Data From Reference
    Alleles (3)
    Genes (23)
    Cell Lines (1)
    Transgenic Constructs (1)