Reference Report

Reference
Citation	Ha, E.M., Lee, K.A., Seo, Y.Y., Kim, S.H., Lim, J.H., Oh, B.H., Kim, J., Lee, W.J. (2009). Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat. Immunol. 10(9): 949--957. (Export to RIS)
FlyBase ID	FBrf0208708
Publication Type	Research paper
PubMed ID	19668222
PubMed Abstract	All metazoan guts are in permanent contact with the microbial realm. However, understanding of the exact mechanisms by which the strength of gut immune responses is regulated to achieve gut-microbe mutualism is far from complete. Here we identify a signaling network composed of complex positive and negative mechanisms that controlled the expression and activity of dual oxidase (DUOX), which 'fine tuned' the production of microbicidal reactive oxygen species depending on whether the gut encountered infectious or commensal microbes. Genetic analyses demonstrated that negative and positive regulation of DUOX was required for normal host survival in response to colonization with commensal and infectious microbes, respectively. Thus, the coordinated regulation of DUOX enables the host to achieve gut-microbe homeostasis by efficiently combating infection while tolerating commensal microbes.
DOI	10.1038/ni.1765
Related Publication(s)
Supplementary material	Online methods. [FBrf0209482]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Immunol.
Title	Nature Immunology
Publication Year	2000-
ISBN/ISSN	1529-2908 1529-2916
Data from Reference
Alleles (16)
	Atf-2^{dsRNA.Scer\UAS} Duox^{dsRNA.Scer\UAS} Duox^Scer\UAS.cHa imd^unspecified lic^{dsRNA.Scer\UAS} Mekk1^GD9945 Mekk1^Ur36 Mkp3^GD8219 Mkp3^P3 Mpk2¹ Mpk2^{dsRNA.Scer\UAS} norpA⁷ PGRP-LC^ΔE Rel^E20 Scer\GAL4^da.G32 Scer\GAL4^NP3084
Constructs (7)
	P{GAL4-da.G32} P{GD8219} P{GD9945} P{UAS-Atf-2.RNAi} P{UAS-Duox.RNAi} P{UAS-lic.RNAi} P{UAS-Mpk2.RNAi}
Genes (21)
	Atf-2 CanA1 CanA-14F CanB CanB2 Dpt Duox imd lic Mekk1 Mkp Mkp3 MKP-4 Mpk2 norpA PGRP-LB PGRP-LC Pp2B-14D puc Rel Scer\GAL4
Natural transposons (1)
	P-element