Reference Report

Reference
Citation	Franzdóttir, S.R., Engelen, D., Yuva-Aydemir, Y., Schmidt, I., Aho, A., Klämbt, C. (2009). Switch in FGF signalling initiates glial differentiation in the Drosophila eye. Nature 460(7256): 758--761. (Export to RIS)
FlyBase ID	FBrf0208713
Publication Type	Research paper
PubMed ID	19597479
PubMed Abstract	The formation of a complex nervous system requires the intricate interaction of neurons and glial cells. Glial cells generally migrate over long distances before they initiate their differentiation, which leads to wrapping and insulation of axonal processes. The molecular pathways coordinating the switch from glial migration to glial differentiation are largely unknown. Here we demonstrate that, within the Drosophila eye imaginal disc, fibroblast growth factor (FGF) signalling coordinates glial proliferation, migration and subsequent axonal wrapping. Glial differentiation in the Drosophila eye disc requires a succession from glia-glia interaction to glia-neuron interaction. The neuronal component of the fly eye develops in the peripheral nervous system within the eye-antennal imaginal disc, whereas glial cells originate from a pool of central-nervous-system-derived progenitors and migrate onto the eye imaginal disc. Initially, glial-derived Pyramus, an FGF8-like ligand, modulates glial cell number and motility. A switch to neuronally expressed Thisbe, a second FGF8-like ligand, then induces glial differentiation. This switch is accompanied by an alteration in the intracellular signalling pathway through which the FGF receptor channels information into the cell. Our findings reveal how a switch from glia-glia interactions to glia-neuron interactions can trigger formation of glial membrane around axonal trajectories. These results disclose an evolutionarily conserved control mechanism of axonal wrapping, indicating that Drosophila might serve as a model to understand glial disorders in humans.
DOI	10.1038/nature08167
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Aberrations (1)
	Df(2R)BSC25
Alleles (24)
	Ecol\lacZ^sty-09143 Ecol\lexA^{repo.T:Scer\GAL4-GAD} htl^AB42 htl^{DN.Scer\UAS.cMb} htl^{dsRNA.Scer\UAS.cFa} htl^{Scer\UAS.T:λ\cI-DD} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} pnt^GD1513 pyr^c02915a pyr^d06722 R^GD9686 rl^GD4697 Rnor\CD2^{Ecol\lexAop.T:Avic\GFP} Scer\GAL4^ey.PH Scer\GAL4^GMR.long Scer\GAL4^GMR.PU Scer\GAL4^Mz97 Scer\GAL4^repo Scer\GAL4^tub.PU stumps^GD10225 sty^GD1156 ths^e02026 ths^GD7730 ths^Scer\UAS.cUa
Constructs (14)
	P{GAL4-ey.H} P{GD1156} P{GD1513} P{GD4697} P{GD7730} P{GD9686} P{GD10225} P{lexAop-rCD2-GFP} P{longGMR-GAL4} P{repo-LexA-GAD} P{UAS-htl.dsRNA.F} P{UAS-htl.λ\cI.M} P{UAS-mCD8::GFP.L} P{UAS-ths.U}
Genes (16)
	Ecol\lacZ Ecol\lexA htl Mmus\Cd8a pnt pyr R Ras64B Ras85D repo rl Rnor\CD2 Scer\GAL4 stumps sty ths
Insertions (3)
	P{GAL4}repo P{PZ}eIF5B⁰⁹¹⁴³ P{XP}pyr^d06722
Natural transposons (1)
	P-element