Reference Report

Reference
Citation	Long, H., Ou, Y., Rao, Y., van Meyel, D.J. (2009). Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila. Development 136(20): 3475--3484. (Export to RIS)
FlyBase ID	FBrf0208798
Publication Type	Research paper
PubMed ID	19783736
PubMed Abstract	The dendritic trees of neurons result from specific patterns of growth and branching, and dendrite branches of the same neuron avoid one another to spread over a particular receptive field. Recognition molecules on the surfaces of dendrites influence these patterning and avoidance processes by promoting attractive, repulsive or adhesive responses to specific cues. The Drosophila transmembrane protein Turtle (Tutl) and its orthologs in other species are conserved members of the immunoglobulin superfamily, the in vivo functions of which are unknown. In Drosophila sensory neurons, we show that the tutl gene is required to restrain dendrite branch formation in neurons with simple arbors, and to promote dendrite self-avoidance in neurons with complex arbors. The cytoplasmic tail of Tutl is dispensable for control of dendrite branching, suggesting that Tutl acts as a ligand or co-receptor for an unidentified recognition molecule to influence the architecture of dendrites and their coverage of receptive territories.
DOI	10.1242/dev.040220
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2L)ed-dp
Alleles (19)
	ab^k02807 ct^C145 Dscam³³ kn^KN2 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^109(2)80 Scer\GAL4²²¹ Scer\GAL4^elav-C155 Scer\GAL4^ppk.1.9 Scer\GAL4^smid-C161 ss^D115.7 trc¹ tutl²³ tutl⁰¹⁰⁸⁵ tutl^f02770 tutl^f03096 tutl^Scer\UAS.cLa tutl^{Δcyto.Scer\UAS} w^+mC
Constructs (5)
	P{ppk-GAL4.1.9} P{UAS-mCD8::GFP.L} P{UAS-tutl.L} P{UAS-tutl.Δcyto} PBac{WHr}
Genes (10)
	ab ct Dscam kn Mmus\Cd8a Scer\GAL4 ss trc tutl w
Insertions (5)
	P{GawB}elav^C155 P{GawB}smid^C161 PBac{WH}tutl^f02770 PBac{WH}tutl^f03096 PBac{WHr}tutl²³
Natural transposons (1)
	P-element