Reference Report

Reference
Citation	Fetting, J.L., Spencer, S.A., Wolff, T. (2009). The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye. Development 136(19): 3323--3333. (Export to RIS)
FlyBase ID	FBrf0208836
Publication Type	Research paper
PubMed ID	19736327
PubMed Abstract	Directed cellular movements are a universal feature of morphogenesis in multicellular organisms. Differential adhesion between the stationary and motile cells promotes these cellular movements to effect spatial patterning of cells. A prominent feature of Drosophila eye development is the 90 degrees rotational movement of the multicellular ommatidial precursors within a matrix of stationary cells. We demonstrate that the cell adhesion molecules Echinoid (Ed) and Friend of Echinoid (Fred) act throughout ommatidial rotation to modulate the degree of ommatidial precursor movement. We propose that differential levels of Ed and Fred between stationary and rotating cells at the initiation of rotation create a permissive environment for cell movement, and that uniform levels in these two populations later contribute to stopping the movement. Based on genetic data, we propose that ed and fred impart a second, independent, ;brake-like' contribution to this process via Egfr signaling. Ed and Fred are localized in largely distinct and dynamic patterns throughout rotation. However, ed and fred are required in only a subset of cells - photoreceptors R1, R7 and R6 - for normal rotation, cells that have only recently been linked to a role in planar cell polarity (PCP). This work also provides the first demonstration of a requirement for cone cells in the ommatidial rotation aspect of PCP. ed and fred also genetically interact with the PCP genes, but affect only the degree-of-rotation aspect of the PCP phenotype. Significantly, we demonstrate that at least one PCP protein, Stbm, is required in R7 to control the degree of ommatidial rotation.
DOI	10.1242/dev.038422
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (26)
	aos^rlt cno² cno^mis1 dgo³⁸⁰ dsh¹ ed¹ ed^1X5 ed^K1102 ed^Scer\UAS.cBa ed^slH8 Egfr^E1 fred^{dsRNA.Scer\UAS} fred^H10 fred^H24 fred^Scer\UAS.cSa fz¹⁹ fz²⁰ pnt¹²⁷⁷ pnt^Δ88 Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^ro.PO spi^s3547 stan^frz3 Vang^stbm-15 Vang^stbm-153
Constructs (5)
	P{GAL4-Hsp70.sev} P{ro-GAL4.O} P{UAS-ed.B} P{UAS-fred.RNAi} P{UAS-fred.S}
Genes (18)
	aos arm cno dgo dsh ed Egfr fred fz pk pnt Rab5 Rab7 Rab11 Scer\GAL4 spi stan Vang
Natural transposons (1)
	P-element