Reference Report

Reference
Citation	Parrish, J.Z., Xu, P., Kim, C.C., Jan, L.Y., Jan, Y.N. (2009). The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63(6): 788--802. (Export to RIS)
FlyBase ID	FBrf0208858
Publication Type	Research paper
PubMed ID	19778508
PubMed Abstract	In addition to establishing dendritic coverage of the receptive field, neurons need to adjust their dendritic arbors to match changes of the receptive field. Here, we show that dendrite arborization (da) sensory neurons establish dendritic coverage of the body wall early in Drosophila larval development and then grow in precise proportion to their substrate, the underlying body wall epithelium, as the larva more than triples in length. This phenomenon, referred to as scaling growth of dendrites, requires the function of the microRNA (miRNA) bantam (ban) in the epithelial cells rather than the da neurons themselves. We further show that ban in epithelial cells dampens Akt kinase activity in adjacent neurons to influence dendrite growth. This signaling between epithelial cells and neurons receiving sensory input from the body wall synchronizes their growth to ensure proper dendritic coverage of the receptive field.
DOI	10.1016/j.neuron.2009.08.006
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (1)
	Df(3L)ban^Δ1
Alleles (64)
	Akt1⁹ Akt1⁰⁴²²⁶ Akt1^GD1361 Akt1^{Scer\UAS.Exel} Akt1^unspecified arm^weep Avic\GFP^1.E.ppk Avic\GFP^arm-weep Avic\GFP^{EGFP.ban.αTub84B} Avic\GFP^{EGFP.αTub84B.B} Avic\GFP^Nrg-G00305 b6-22^b6-22 ban^A.Scer\UAS ban^{B.Scer\UAS.T:Avic\GFP-EGFP} ban^{C.Scer\UAS.T:Avic\GFP-EGFP} ban^{D.Scer\UAS.T:Avic\GFP-EGFP} ban^Scer\UAS.cPa br¹ Cdk4³ CG3511² chico¹ Dcr-2^Scer\UAS.cDa Eip75B^A81 esc²¹ fry¹ gt¹ gt^E6 gt^unspecified Gαs^B19 Hph^unspecified InR^93Dj-4 InR^E19 klu⁰⁹⁰³⁶ l(2)gl¹ l(2)gl⁴ Mmus\Cd8a^{Scer\UAS.LG.T:Disc\RFP-mRFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Pdp1^P205 Pi3K92E^{CAAX.Scer\UAS} Pten^Scer\UAS.cHa Rheb^AV4 sav³ Scer\GAL4^69B Scer\GAL4²²¹ Scer\GAL4⁴⁷⁷ Scer\GAL4^Act.PU Scer\GAL4^arm.PS Scer\GAL4^elav-C155 Scer\GAL4^hs.PB Scer\GAL4^Lsp2.PH Scer\GAL4^Mai311 Scer\GAL4^Mhc.PW Scer\GAL4^P0206 Scer\GAL4^ppk.PG Scer\GAL4^ss.cKa Scer\GAL4^twi.PG shf² shr¹ slik^KG04837 ss¹³⁴ step^k08110 Tor^k17004 Tor^ΔP twf^EP3701
Constructs (25)
	P{Act-GAL4.U} P{GAL4-arm.S} P{GAL4-Hsp70.PB} P{GAL4-Mhc.W} P{GAL4-twi.G} P{GawB} P{GD1361} P{Lsp2-GAL4.H} P{ppk-EGFP.1} P{ppk-GAL4.G} P{ss-Gal4.K} P{Tub-EGFP.B} P{Tub-EGFP.ban} P{UAS-A} P{UAS-Akt1.Exel} P{UAS-B} P{UAS-ban.PX} P{UAS-C} P{UAS-D} P{UAS-Dcr-2.D} P{UAS-mCD8::GFP.L} P{UAS-mCD8.mRFP.LG} P{UAS-Pi3K92E.CAAX} P{UAS-Pten.H} P{Wee-P.un1}
Genes (39)
	Akt1 arm Avic\GFP b6-22 ban br Cdk4 CG3511 chico Dcr-2 Eip75B esc fry gt Gαs Hph InR klu l(2)gl Mmus\Cd8a Nrg Pdp1 Pi3K92E ppk Pten Rac1 Rheb rpr S6k sav Scer\GAL4 shf shr slik ss step Tor twf αTub84B
Insertions (17)
	?{}gt¹a P{EP}twf^EP3701 P{GAL4}P0206 P{GawB}69B P{GawB}221 P{GawB}477 P{GawB}elav^C155 P{GawB}Mai311 P{lacW}step^k08110 P{lacW}Tor^k17004 P{Mae-UAS.6.11}Rheb^AV4 P{PTT-GA}Nrg^G00305 P{PZ}Akt1⁰⁴²²⁶ P{PZ}klu⁰⁹⁰³⁶ P{ry11}chico¹ P{SUPor-P}slik^KG04837 P{Wee-P.un1}arm^weep
Natural transposons (1)
	P-element
Transcripts (6)
	Avic\GFP^1.E.ppkRA Avic\GFP^{EGFP.ban.αTub84B}RA Avic\GFP^{EGFP.αTub84B.B}RA Scer\GAL4²²¹RA Scer\GAL4^ppk.PGRA Scer\GAL4^ss.cKaRA