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Reference Report
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| Citation | Zhou, X., Duan, X., Qian, J., Li, F. (2009). Abundant conserved microRNA target sites in the 5'-untranslated region and coding sequence. Genetica 137(2): 159--164. (Export to RIS) | ||
| FlyBase ID | FBrf0208912 | ||
| Publication Type | Research paper | ||
| PubMed ID | 19578934 | ||
| PubMed Abstract | Recent studies have shown that miRNAs can target the promoter and CDS region. Thus, we predicted miRNA target sites in the 5'-UTR, CDS and 3'-UTR of Homo sapiens, Mus musculus and Drosophila melanogaster using miRanda and TargetScan. Target-site densities normalized with the average region length were higher in the 5'-UTR than 3'-UTR in all three organisms but were lower in the negative data set. Interestingly, the putative target sites were more conserved than non-target regions in both the 5'-UTR and 3'-UTR, implying that target sites in the 5'-UTR are subject to high selective pressure and might be functional. In Drosophila, 48 of 78 (61.5%) miRNAs showed high similarities with predicted siRNAs. Based on the results of previous experimental studies and a large-scale statistical analysis, we conclude that miRNA-mediated regulation is not limited to the 3'-UTR. However, the functionality of target sites in the 5'-UTR and CDS requires thorough investigation. | ||
| DOI | 10.1007/s10709-009-9378-7 | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Genetica | ||
| Title | Genetica | ||
| Publication Year | 1919- | ||
| ISBN/ISSN | 0016-6707 | ||
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Data from Reference
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| Genes (26)
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