Reference Report

Reference
Citation	Mathew, S.J., Kerridge, S., Leptin, M. (2009). A small genomic region containing several loci required for gastrulation in Drosophila. PLoS ONE 4(10): e7437. (Export to RIS)
FlyBase ID	FBrf0208913
Publication Type	Research paper
PubMed ID	19823683
PubMed Abstract	Genetic screens in Drosophila designed to search for loci involved in gastrulation have identified four regions of the genome that are required zygotically for the formation of the ventral furrow. For three of these, the genes responsible for the mutant phenotypes have been found. We now describe a genetic characterization of the fourth region, which encompasses the cytogenetic interval 24C3-25B, and the mapping of genes involved in gastrulation in this region. We have determined the precise breakpoints of several existing deficiencies and have generated new deficiencies. Our results show that the region contains at least three different loci associated with gastrulation effects. One maternal effect gene involved in ventral furrow formation maps at 24F but could not be identified. For a second maternal effect gene which is required for germ band extension, we identify a candidate gene, CG31660, which encodes a G protein coupled receptor. Finally, one gene acts zygotically in ventral furrow formation and we identify it as Traf4.
DOI	10.1371/journal.pone.0007437
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Aberrations (26)
	C(2)v Df(2L)dp-cl-h3 Df(2L)dp-h19 Df(2L)dp-h24 Df(2L)dp-h25 Df(2L)dp-h28 Df(2L)ed1 Df(2L)ED247 Df(2L)ED250 Df(2L)ED250A Df(2L)ED251 Df(2L)ED252 Df(2L)ED256 Df(2L)ED258 Df(2L)ED260 Df(2L)ED262 Df(2L)ED3006-2L Df(2L)ed-dp Df(2L)Exel6010 Df(2L)Exel9062 Df(2L)M24F11 Df(2L)M24F-B Df(2L)sc19-4 Df(2L)sc19-5 Df(2L)sc19-8 Df(2L)sc19-10
Alleles (15)
	l(2)24Fa¹ pog¹ Psf2^SH0805 Tps1^a18 Tps1^a19 Tps1^b2 Tps1^h10 Tps1^sz31 Traf4³ Traf4^EP578 Traf4^ex1 Traf4^L2 Traf4^{Scer\SceI.RS.cMa} tutl^jf4 tutl^k14703
Constructs (2)
	P{FRT(Traf4.Scer\SceI.RS)} PBac{RB}
Genes (31)
	Aco Atet bcn92 bowl CG3036 CG3225 CG3652 CG11926 CG11927 CG11929 CG12677 CG15429 CG15436 CG15631 CG15634 dp fog ft ine l(2)24Fa l(2)05714 l(2)k05819 mRpS2 pog Psf2 RpL27A T48 Tps1 Traf4 tutl vkg
Insertions (10)
	P{EP}Traf4^EP578 P{lacW}Psf2^SH0805 P{lacW}tutl^k14703 P{RS3}CB-5668-3 P{RS5}5-SZ-3156 P{RS5}CG15439^5-HA-1707 P{RS5}His3.3A^5-HA-1043 P{XP}d01652 PBac{RB}pog^e03006 PBac{WH}CG15626^f03581
Natural transposons (1)
	P-element