Reference Report

Reference
Citation	Claridge-Chang, A., Roorda, R.D., Vrontou, E., Sjulson, L., Li, H., Hirsh, J., Miesenböck, G. (2009). Writing memories with light-addressable reinforcement circuitry. Cell 139(2): 405--415. (Export to RIS)
FlyBase ID	FBrf0208958
Publication Type	Research paper
PubMed ID	19837039
PubMed Abstract	Dopaminergic neurons are thought to drive learning by signaling changes in the expectations of salient events, such as rewards or punishments. Olfactory conditioning in Drosophila requires direct dopamine action on intrinsic mushroom body neurons, the likely storage sites of olfactory memories. Neither the cellular sources of the conditioning dopamine nor its precise postsynaptic targets are known. By optically controlling genetically circumscribed subsets of dopaminergic neurons in the behaving fly, we have mapped the origin of aversive reinforcement signals to the PPL1 cluster of 12 dopaminergic cells. PPL1 projections target restricted domains in the vertical lobes and heel of the mushroom body. Artificially evoked activity in a small number of identifiable cells thus suffices for programming behaviorally meaningful memories. The delineation of core reinforcement circuitry is an essential first step in dissecting the neural mechanisms that compute and represent valuations, store associations, and guide actions.
DOI	10.1016/j.cell.2009.08.034
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (9)
	Avic\GFP^PA.Scer\UAS Disc\RFP^Mef2.mb247 Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rnor\P2rx2^Scer\UAS.cLa rut²⁰⁸⁰ Scer\GAL4^Ddc.HL9 Scer\GAL4^ple.PF Scer\GAL80^ts.αTub84B
Constructs (8)
	P{Ddc-GAL4.HL9} P{mb247-DsRed} P{ple-GAL4.F} P{tubP-GAL80^ts} P{UAS-GFP.Pa} P{UAS-Hsap\KCNJ2.EGFP} P{UAS-mCD8::GFP.L} P{UAS-Rnor\P2rx2.L}
Genes (11)
	Avic\GFP brp Ddc Disc\RFP Hsap\KCNJ2 Mmus\Cd8a ple Rnor\P2rx2 rut Scer\GAL4 Scer\GAL80
Transcripts (2)
	Scer\GAL4^Ddc.HL9RA Scer\GAL4^ple.PFRA