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Citation
Fox, D.T., Spradling, A.C. (2009). The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.  Cell Stem Cell 5(3): 290--297.
FlyBase ID
FBrf0209061
Publication Type
Research paper
Abstract
The adult Drosophila hindgut was recently reported to contain active, tissue-replenishing stem cells, like those of the midgut, but located within an anterior ring so as to comprise a single giant crypt. In contrast to this view, we observed no active stem cells and little cell turnover in adult hindgut tissue based on clonal marking and BrdU incorporation studies. Again contradicting the previous proposal, we showed that the adult hindgut is not generated by anterior stem cells during larval/pupal development. However, severe tissue damage within the hindgut elicits cell proliferation within a ring of putative quiescent stem cells at the anterior of the pylorus. Thus, the hindgut does not provide a model of tissue maintenance by constitutively active stem cells, but has great potential to illuminate mechanisms of stress-induced tissue repair.
PubMed ID
PubMed Central ID
PMC2772661 (PMC) (EuropePMC)
Related Publication(s)
Note
Stem cell in the adult Drosophila hindgut: just a sleeping beauty.
Xie, 2009, Cell Stem Cell 5(3): 227--228 [FBrf0208820]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Stem Cell
    Title
    Cell Stem Cell
    Publication Year
    2007--
    ISBN/ISSN
    1934-5909 1875-9777
    Data From Reference