Reference Report

Reference
Citation	Fox, D.T., Spradling, A.C. (2009). The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. Cell Stem Cell 5(3): 290--297. (Export to RIS)
FlyBase ID	FBrf0209061
Publication Type	Research paper
PubMed ID	19699165
PubMed Abstract	The adult Drosophila hindgut was recently reported to contain active, tissue-replenishing stem cells, like those of the midgut, but located within an anterior ring so as to comprise a single giant crypt. In contrast to this view, we observed no active stem cells and little cell turnover in adult hindgut tissue based on clonal marking and BrdU incorporation studies. Again contradicting the previous proposal, we showed that the adult hindgut is not generated by anterior stem cells during larval/pupal development. However, severe tissue damage within the hindgut elicits cell proliferation within a ring of putative quiescent stem cells at the anterior of the pylorus. Thus, the hindgut does not provide a model of tissue maintenance by constitutively active stem cells, but has great potential to illuminate mechanisms of stress-induced tissue repair.
DOI	10.1016/j.stem.2009.06.003
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell Stem Cell
Title	Cell Stem Cell
Publication Year	2007--
ISBN/ISSN	1934-5909
Data from Reference
Alleles (10)
	Avic\GFP^Scer\UAS.cUa Cbβ\DT-A^I.Scer\UAS Ecol\lacZ^{Ddc.be2.E(spl).m8} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rcom\RA^Scer\UAS.cSa rpr^Scer\UAS.cZa Scer\GAL4^byn-Gal4 Scer\GAL4^{Scer\FRT.Rnor\CD2.αTub84B} Scer\GAL80^ts.αTub84B W^Scer\UAS.cZa
Constructs (9)
	P{Ddc.E(spl)-lacZ.Gbe.m8} P{GAL4-αTub84B(FRT.CD2).P} P{tubP-GAL80^ts} P{UAS-Cbβ\DT-A.I} P{UAS-GFP.U} P{UAS-mCD8::GFP.L} P{UAS-RA} P{UAS-rpr.Z} P{UAS-W.Z}
Genes (11)
	Avic\GFP byn Cbβ\DT-A Ecol\lacZ Mmus\Cd8a Rcom\RA rpr Scer\GAL4 Scer\GAL80 W wg
Insertions (1)
	P{GawB}byn^Gal4