Reference Report

Reference
Citation	Baena-Lopez, L.A., Franch-Marro, X., Vincent, J.P. (2009). Wingless promotes proliferative growth in a gradient-independent manner. Sci. Signal. 2(91): ra60. (Export to RIS)
FlyBase ID	FBrf0209070
Publication Type	Research paper
PubMed ID	19809090
PubMed Abstract	Morphogens form concentration gradients that organize patterns of cells and control growth. It has been suggested that, rather than the intensity of morphogen signaling, it is its gradation that is the relevant modulator of cell proliferation. According to this view, the ability of morphogens to regulate growth during development depends on their graded distributions. Here, we describe an experimental test of this model for Wingless, one of the key organizers of wing development in Drosophila. Maximal Wingless signaling suppresses cellular proliferation. In contrast, we found that moderate and uniform amounts of exogenous Wingless, even in the absence of endogenous Wingless, stimulated proliferative growth. Beyond a few cell diameters from the source, Wingless was relatively constant in abundance and thus provided a homogeneous growth-promoting signal. Although morphogen signaling may act in combination with as yet uncharacterized graded growth-promoting pathways, we suggest that the graded nature of morphogen signaling is not required for proliferation, at least in the developing Drosophila wing, during the main period of growth.
DOI	10.1126/scisignal.2000360
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Sci. Signal.
Title	Science signaling
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ISBN/ISSN	1937-9145
Data from Reference
Alleles (9)
	arm^{S10.Scer\UAS.T:Hsap\MYC} BacA\p35^Scer\UAS.cHa Scer\GAL4^en-e16E Scer\GAL4^hh-Gal4 Scer\GAL4^nub-AC-62 Scer\GAL80^ts.αTub84B wg^{C104S.Scer\UAS} wg^l-17 wg^{S239A.Scer\UAS.T:Ivir\HA1}
Constructs (5)
	P{tubP-GAL80^ts} P{UAS-arm.S10} P{UAS-p35.H} P{UAS-wg.C104S} P{UAS-wg.HA.S239A}
Genes (10)
	arm BacA\p35 dlp His3 Hsp23 Scer\GAL4 Scer\GAL80 sens vg wg
Insertions (3)
	P{en2.4-GAL4}e16E P{GAL4}hh^Gal4 P{GawB}nubbin-AC-62
Natural transposons (1)
	P-element