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Citation
Anamika, K., Abhinandan, K.R., Deshmukh, K., Srinivasan, N. (2009). Classification of nonenzymatic homologues of protein kinases.  Comp. Funct. Genomics (): 365637.
FlyBase ID
FBrf0209106
Publication Type
Research paper
Abstract

Protein Kinase-Like Non-kinases (PKLNKs), which are closely related to protein kinases, lack the crucial catalytic aspartate in the catalytic loop, and hence cannot function as protein kinase, have been analysed. Using various sensitive sequence analysis methods, we have recognized 82 PKLNKs from four higher eukaryotic organisms, namely, Homo sapiens, Mus musculus, Rattus norvegicus, and Drosophila melanogaster. On the basis of their domain combination and function, PKLNKs have been classified mainly into four categories: (1) Ligand binding PKLNKs, (2) PKLNKs with extracellular protein-protein interaction domain, (3) PKLNKs involved in dimerization, and (4) PKLNKs with cytoplasmic protein-protein interaction module. While members of the first two classes of PKLNKs have transmembrane domain tethered to the PKLNK domain, members of the other two classes of PKLNKs are cytoplasmic in nature. The current classification scheme hopes to provide a convenient framework to classify the PKLNKs from other eukaryotes which would be helpful in deciphering their roles in cellular processes.

PubMed ID
PubMed Central ID
PMC2754085 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Comp. Funct. Genomics
    Title
    Comparative and Functional Genomics
    Publication Year
    2001-
    ISBN/ISSN
    1531-6912
    Data From Reference