Reference Report

Reference
Citation	Gorchakov, A.A., Alekseyenko, A.A., Kharchenko, P., Park, P.J., Kuroda, M.I. (2009). Long-range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X. Genes Dev. 23(19): 2266--2271. (Export to RIS)
FlyBase ID	FBrf0209136
Publication Type	Research paper
PubMed ID	19797766
PubMed Abstract	Dosage compensation in Drosophila melanogaster males is achieved via targeting of male-specific lethal (MSL) complex to X-linked genes. This is proposed to involve sequence-specific recognition of the X at approximately 150-300 chromatin entry sites, and subsequent spreading to active genes. Here we ask whether the spreading step requires transcription and is sequence-independent. We find that MSL complex binds, acetylates, and up-regulates autosomal genes inserted on X, but only if transcriptionally active. We conclude that a long-sought specific DNA sequence within X-linked genes is not obligatory for MSL binding. Instead, linkage and transcription play the pivotal roles in MSL targeting irrespective of gene origin and DNA sequence.
DOI	10.1101/gad.1840409
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (7)
	CG3702^TrojanHorse CG3702^{TrojanHorseΔ} msl-3¹ msl-3^T:Zzzz\TAP RpL40^TrojanHorse RpL40^{TrojanHorseΔ} w^+*
Constructs (4)
	P{msl-3.TAP} P{TrojanElephant} P{TrojanHorse} P{TrojanHorseΔ}
Genes (8)
	CG3702 His3 His4 msl-2 msl-3 RpL17 RpL40 w
Insertions (5)
	P{CaryP}attP3 P{CaryP}attP18 P{TrojanHorse}attP3 P{TrojanHorse}attP18 P{TrojanHorseΔ}attP18
Natural transposons (1)
	P-element