Reference Report

Reference
Citation	Li, H., Lu, Y. (2009). Phenotypic inheritance induced by hairpin RNA in Drosophila. Acta Biochim. Biophys. Sinica 41(11): 922--928. (Export to RIS)
FlyBase ID	FBrf0209274
Publication Type	Research paper
PubMed ID	19902126
PubMed Abstract	Phenotypic inheritance induced by RNA has been documented in mouse and Caenorhabditis elegans. Here we report a similar inheritance in Drosophila. Mutant phenotypes of eye defects and antenna duplication generated from the crossing of one RNA interference (RNAi) transgenic line harboring one hairpin RNA transgene with a GAL4 driver line were inherited independently of the GAL4 driver. Hairpin RNA injection experiments demonstrated that the hairpin RNA could induce heritable mutant-like phenotypes on the eye and antenna. The penetrance of mutant phenotypes was reduced when the mutants were crossed to ago1 and piwi mutants. Our data suggest that hairpin RNA can induce phenotypic inheritance in Drosophila.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Acta Biochim. Biophys. Sinica
Title	Acta Biochimica Biophysica Sinica [Zhongguo ke xue yuan]
Publication Year	2004-
ISBN/ISSN	1672-9145 1745-7270
Data from Reference
Alleles (7)
	AGO1⁰⁴⁸⁴⁵ E2f^{dsRNA.A.Scer\UAS} E2f^{dsRNA.B.Scer\UAS} E2f^{dsRNA.C.Scer\UAS} Ecol\lacZ^{Scer\UAS.T:SV40\nls2} piwi¹ Scer\GAL4^I-76-D
Constructs (4)
	P{UAS-E2f.A.RNAi} P{UAS-E2f.B.RNAi} P{UAS-E2f.C.RNAi} P{UAS-lacZ.NZ}
Genes (5)
	AGO1 E2f Ecol\lacZ piwi Scer\GAL4
Insertions (3)
	P{GawB}I-76-D P{PZ}AGO1⁰⁴⁸⁴⁵ P{PZ}piwi¹
Natural transposons (1)
	P-element