Reference Report

Reference
Citation	Hong, W., Zhu, H., Potter, C.J., Barsh, G., Kurusu, M., Zinn, K., Luo, L. (2009). Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map. Nat. Neurosci. 12(12): 1542--1550. (Export to RIS)
FlyBase ID	FBrf0209355
Publication Type	Research paper
PubMed ID	19915565
PubMed Abstract	Olfactory systems utilize discrete neural pathways to process and integrate odorant information. In Drosophila, axons of first-order olfactory receptor neurons (ORNs) and dendrites of second-order projection neurons (PNs) form class-specific synaptic connections at approximately 50 glomeruli. The mechanisms underlying PN dendrite targeting to distinct glomeruli in a three-dimensional discrete neural map are unclear. We found that the leucine-rich repeat (LRR) transmembrane protein Capricious (Caps) was differentially expressed in different classes of PNs. Loss-of-function and gain-of-function studies indicated that Caps instructs the segregation of Caps-positive and Caps-negative PN dendrites to discrete glomerular targets. Moreover, Caps-mediated PN dendrite targeting was independent of presynaptic ORNs and did not involve homophilic interactions. The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation.
DOI	10.1038/nn.2442
Related Publication(s)
Supplementary material	Online methods. [FBrf0211301]
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Nat. Neurosci.
Title	Nature Neuroscience
Publication Year	1998-
ISBN/ISSN	1097-6256
Data from Reference
Aberrations (2)
	Df(3L)Exel6118 Df(3L)trn^Δ17
Alleles (18)
	caps^C28fs caps^Del1 caps^GS10839 caps^Scer\UAS.cSa Mmus\Cd8a^{Scer\FRT.Scer\UAS.cHa.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.cHa.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rcom\RA^Scer\UAS.cSa Rcom\RA^{Scer\UAS.Scer\FRT} Scer\FLP1^ey.PN Scer\FLP1^GH146.PP Scer\GAL4^AM29 Scer\GAL4^caps-NP3294 Scer\GAL4^GH146 Scer\GAL4^Mz19 Scer\GAL4^peb-GAL4 Scer\GAL4^unspecified trn^28.4
Constructs (7)
	P{ey-FLP.N} P{PUFWTRA} P{UAS(FRT.stop)mCD8-GFP.H} P{UAS(-FRT)mCD8-GFP.H} P{UAS-caps.S} P{UAS-mCD8::GFP.L} PBac{GH146-FLPo.P}
Genes (10)
	brp CadN caps Mmus\Cd8a peb Rcom\RA Scer\FLP1 Scer\GAL4 T:Avic\GFP trn
Insertions (6)
	P{GAL4}AM29 P{GAL4}peb^GAL4 P{GawB}caps^NP3294 P{GawB}GH146 P{GawB}Mz19 P{GSV6}caps^GS10839
Polypeptides (1)
	Scer\FLP1^GH146.PPXP
Transcripts (4)
	Scer\GAL4^AM29RA Scer\GAL4^caps-NP3294RA Scer\GAL4^Mz19RA Scer\GAL4^peb-GAL4RA